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Biological exposure assessment to tetrachloroethylene for workers in the dry cleaning industry.

Authors
McKernan-LT; Ruder-AM; Petersen-MR; Hein-MJ; Forrester-CL; Sanderson-WT; Ashley-DL; Butler-MA
Source
Environ Health Glob Access Sci Source 2008 Apr; 7:12
NIOSHTIC No.
20033720
Abstract
Background: the purpose of this study was to assess the feasibility of conducting biological tetrachloroethylene (perchloroethylene, PCE) exposure assessments of dry cleaning employees in conjunction with evaluation of possible PCE health effects. Methods: eighteen women from four dry cleaning facilities in southwestern Ohio were monitored in a pilot study of workers with PCE exposure. Personal breathing zone samples were collected from each employee on two consecutive work days. Biological monitoring included a single measurement of PCE in blood and multiple measurements of pre- and post-shift PCE in exhaled breath and trichloroacetic acid (TCA) in urine. Results: post-shift PCE in exhaled breath gradually increased throughout the work week. Statistically significant correlations were observed among the exposure indices. Decreases in PCE in exhaled breath and TCA in urine were observed after two days without exposure to PCE. A mixed-effects model identified statistically significant associations between PCE in exhaled breath and airborne PCE time weighted average (TWA) after adjusting for a random participant effect and fixed effects of time and body mass index. Conclusion: although comprehensive, our sampling strategy was challenging to implement due to fluctuating work schedules and the number (pre- and post-shift on three consecutive days) and multiplicity (air, blood, exhaled breath, and urine) of samples collected. PCE in blood is the preferred biological index to monitor exposures, but may make recruitment difficult. PCE TWA sampling is an appropriate surrogate, although more field intensive. Repeated measures of exposure and mixed-effects modeling may be required for future studies due to high within-subject variability. Workers should be monitored over a long enough period of time to allow the use of a lag term.
Keywords
Workplace-monitoring; Work-environment; Occupational-exposure; Analytical-methods; Statistical-analysis; Inhalation-studies; Chemical-properties; Dry-cleaning-industry; Dry-cleaning-solvents; Biochemical-analysis; Biochemical-tests; Biochemistry; Biological-effects; Biological-factors; Biological-monitoring; Blood-tests; Breathing-zone; Models; Time-weighted-average-exposure; Solvents; Solvent-vapors; Humans; Women; Breathing-zone; Exposure-assessment
Contact
Avima M Ruder, Centers for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226, USA
Publication Date
20080415
Document Type
Journal Article
Email Address
LTaylor@cdc.gov
Funding Type
Grant
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008491
ISSN
1476-069X
NIOSH Division
DSHEFS
Priority Area
Manufacturing
Source Name
Environmental Health: A Global Access Science Source
State
OH; NY; NJ; TN; DC
Performing Organization
University of Iowa
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