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Occupational exposure to pesticides and risk of adult brain tumors.

Authors
Samanic-CM; De Roos-AJ; Stewart-PA; Rajaraman-P; Waters-MA; Inskip-PD
Source
Am J Epidemiol 2008 Apr; 167(8):976-985
NIOSHTIC No.
20033719
Abstract
The authors examined incident glioma and meningioma risk associated with occupational exposure to insecticides and herbicides in a hospital-based, case-control study of brain cancer. Cases were 462 glioma and 195 meningioma patients diagnosed between 1994 and 1998 in three US hospitals. Controls were 765 patients admitted to the same hospitals for nonmalignant conditions. Occupational histories were collected during personal interviews. Exposure to pesticides was estimated by use of a questionnaire, combined with pesticide measurement data abstracted from published sources. Using logistic regression models, the authors found no association between insecticide and herbicide exposures and risk for glioma and meningioma. There was no association between glioma and exposure to insecticides or herbicides, in men or women. Women who reported ever using herbicides had a significantly increased risk for meningioma compared with women who never used herbicides (odds ratio = 2.4, 95% confidence interval: 1.4, 4.3), and there were significant trends of increasing risk with increasing years of herbicide exposure (p = 0.01) and increasing cumulative exposure (p = 0.01). There was no association between meningioma and herbicide or insecticide exposure among men. These findings highlight the need to go beyond job title to elucidate potential carcinogenic exposures within different occupations.
Keywords
Agricultural-industry; Agriculture; Pesticides-and-agricultural-chemicals; Worker-health; Carcinogenicity; Carcinogens; Carcinomas; Brain-disorders; Brain-tumors; Herbicides; Men; Risk-factors; Women; Statistical-analysis; Mathematical-models
Contact
Claudine M. Samanic, US Dept HHS, Division of Cancer Epidemiology & Genetics, NCI, NIH, 6120 Execut Blvd,Room 8003, Rockville, MD 20852
CODEN
AJEPAS
Publication Date
20080415
Document Type
Journal Article
Email Address
samanicc@mail.nih.gov
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Issue of Publication
8
ISSN
0002-9262
NIOSH Division
DSHEFS
Priority Area
Agriculture, Forestry and Fishing
Source Name
American Journal of Epidemiology
State
OH; MD; WA
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