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Respiratory inflammatory responses among occupants of a water-damaged office building.

Authors
Akpinar-Elci-M; Siegel-PD; Cox-Ganser-JM; Stemple-KJ; White-SK; Hilsbos-K; Weissman-DN
Source
Indoor Air 2008 Apr; 18(2):125-130
NIOSHTIC No.
20033530
Abstract
The National Institute for Occupational Safety and Health (NIOSH) received a request for evaluation of a water-damaged office building which housed approximately 1300 employees. Workers reported respiratory conditions that they perceived to be building related. We hypothesized that these symptoms were associated with airways inflammation. To test this hypothesis, we assessed airways inflammation in employees using exhaled breath condensate (EBC) and the fraction of exhaled nitric oxide (FENO). In September 2001, a health questionnaire was offered to all employees. Based on this questionnaire, NIOSH invited 356 symptomatic and asymptomatic employees to participate in a medical survey. In June 2002, these employees were offered questionnaire, spirometry, methacholine challenge test, allergen skin prick testing, EBC and FENO. FENO or EBC were completed by 239 participants. As smoking is highly related to the measurements that we used in this study, we included only the 207 current non-smokers in the analyses. EBC interleukin-8 (IL-8) levels, but not nitrite, were significantly higher among workers with respiratory symptoms and in the physician-diagnosed asthmatic group. Of the analyses assessed, EBC IL-8 showed the most significant relationship with a number of symptoms and physician-diagnosed asthma.
Keywords
Allergic-reactions; Fungal-infections; Fungal-diseases; Fungi; Air-contamination; Air-quality; Breathing; Immune-system-disorders; Qualitative-analysis; Questionnaires; Respiratory-irritants; Respiratory-hypersensitivity; Allergens
Contact
M. Akpinar-Elci, 2505 Surrey Lane, Greenville, NC 27858
CODEN
INAIE5
Publication Date
20080401
Document Type
Journal Article
Email Address
makpinarelci@gmail.com
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0905-6947
NIOSH Division
HELD
Source Name
Indoor Air
State
WV; NC
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