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The influence of spray properties on intranasal deposition.

Authors
Foo-MY; Cheng-YS; Su-WC; Donovan-MD
Source
J Aerosol Med 2007 Winter; 20(4):495-508
NIOSHTIC No.
20033339
Abstract
While numerous devices, formulations, and spray characteristics have been shown to influence nasal deposition efficiency, few studies have attempted to identify which of these interacting factors plays the greatest role in nasal spray deposition. The deposition patterns of solutions with a wide range of surface tensions and viscosities were measured using an MRI-derived nasal cavity replica. The resulting spray plumes had angles between 29 degrees and 80 degrees and contained droplet sizes (D(v50)) from 37-157 microm. Each formulation contained rhodamine 590 as a fluorescent marker for detection. Administration angles of 30 degrees , 40 degrees , or 50 degrees above horizontal were tested to investigate the role of user technique on nasal deposition. The amount of spray deposited within specific regions of the nasal cavity was determined by disassembling the replica and measuring the amount of rhodamine retained in each section. Most of the spray droplets were deposited onto the anterior region of the model, but sprays with small plume angles were capable of reaching the turbinate region with deposition efficiencies approaching 90%. Minimal dependence on droplet size, viscosity, or device was observed. Changes in inspiratory flow rate (0-60 L/min) had no significant effect on turbinate deposition efficiency. Both plume angle and administration angle were found to be important factors in determining deposition efficiency. For administration angles of 40 degrees or 50 degrees, maximal turbinate deposition efficiency (30-50%) occurred with plume angles of 55-65 degrees, whereas a 30 degrees administration angle gave an approximately 75% deposition efficiency for similar plume angles. Deposition efficiencies of approximately 90% could be achieved with plume angles <30 degrees using 30 degrees administration angles. Both the plume angle and administration angle are critical factors in determining deposition efficiency, while many other spray parameters, including particle size, have relatively minor influences on deposition within the nasal cavity.
Keywords
Aerosols; Aerosol-particles; Particle-aerodynamics; Particulate-sampling-methods; Air-monitoring; Air-sampling-techniques; Statistical-analysis; Respiratory-function-tests; Qualitative-analysis; Nasal-cavity; Nasal-disorders; Olfactory-disorders
Contact
Maureen D. Donovan, Ph.D. University of Iowa College of Pharmacy 115 S. Grand Ave Iowa City, IA 52242
CODEN
JAEMEP
Publication Date
20071201
Document Type
Journal Article
Email Address
maureen-donovan@uiowa.edu
Funding Type
Grant
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003900
Issue of Publication
4
ISSN
0894-2684
Source Name
Journal of Aerosol Medicine
State
GA; NM; IA
Performing Organization
Lovelace Biomedical & Environmental Research
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