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The localization of vascular endothelial growth factor in a repetitively loaded tendon in vivo: an immunohistological study.

Nakama-LH; King-KB; Rempel-DM
Trans Annu Meet Orthop Res Soc 2004 Mar; 50:0860
Vascular Endothelial Growth Factor (VEGF) is one of the most important angiogenic components of tissue healing. In vitro and in vivo studies have shown that VEGF is responsible for stimulating the proliferation of microvascular endothelial cells, inducing angiogenesis and rendering the microvasculature hyperpermeable. In the tendon, expression of VEGF can be up-regulated by both mechanical and biochemical stimuli that includes hypoxia and the presence of other growth factors. Recent studies have shown that in the injured tendon, the highest levels of VEGF occur after inflammation when it acts as a potent stimulator of angiogenesis. The ingrowth of new blood vessels towards the repair site from within the healing tendon appears necessary for healing to occur. Currently, little is known about the role that VEGF and other growth factors play in tendon loading and injury. Elucidating the cellular and molecular pathways that occur during this period may lead to a better understanding of mechanisms behind tendon healing and remodeling. Our laboratory has developed a rabbit model of epicondylitis in which the flexor digitorum profundus (FDP) muscle is repeatedly stimulated against a load. The purpose of this study was to evaluate the regional variation of VEGF staining cells in the FDP tendon at the epicondyle in response to repetitive loading.
In-vivo-studies; Injuries; Laboratory-animals; Animal-studies; Muscles; Repetitive-work; Cumulative-trauma-disorders; Cumulative-trauma; Musculoskeletal-system; Musculoskeletal-system-disorders; Biomechanics; Laboratory-animals; Models
University of California, 1301 South 46th Street. Building 163, Richmond, CA 94804
Publication Date
Document Type
Abstract; Conference/Symposia Proceedings
Funding Type
Fiscal Year
NTIS Accession No.
NTIS Price
Identifying No.
Priority Area
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Source Name
Transactions of the Annual Meeting of the Orthopaedic Research Society
Performing Organization
University of California - San Francisco