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An in vivo model for entrapment neuropathy due to repeated finger loading.

Authors
Rempel-D; King-K; Robertsson-J; Dahlin-LB; Abrahmsson-S
Source
Trans Annu Meet Orthop Res Soc 2001 Feb; 47:0734
NIOSHTIC No.
20033287
Abstract
Carpal tunnel syndrome is the most common entrapment neuropathy and accounts for high levels of disability in the workplace. Carpal tunnel syndrome may be caused by repetitive, forceful fingertip loading; however, the mechanisms of injury and the relationships between force-duration and injury are not fully known. Knowledge of the injurious mechanical factors (e.g., load rate, number of repetition cycles, peak load, etc.) would be useful in developing primary and secondary preventive measures. However, these mechanistic details will primarily emerge with the development of an appropriate animal model. The purpose of this study was to develop and validate a rabbit model of median neuropathy at the wrist due to repetitive loading of the flexor digitorum profundus (FDP) muscle. The rabbit forearm, carpal tunnel, fingers and nerve anatomy are roughly similar to the human.
Keywords
In-vivo-studies; Injuries; Laboratory-animals; Animal-studies; Muscles; Repetitive-work; Cumulative-trauma-disorders; Cumulative-trauma; Musculoskeletal-system; Musculoskeletal-system-disorders; Biomechanics; Laboratory-animals; Models; Tissue-disorders; Carpal-tunnel-syndrome
Publication Date
20010201
Document Type
Abstract; Conference/Symposia Proceedings
Email Address
rempel@itsa.ucsf.edu
Funding Type
Grant
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R03-OH-003664; Grant-Number-R01-OH-007359
ISSN
0149-6433
Priority Area
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Source Name
Transactions of the Annual Meeting of the Orthopaedic Research Society
State
CA
Performing Organization
University of California - San Francisco
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