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The localization of connective tissue growth factor in a cyclically loaded tendon at the epicondyle in an in vivo model of tendinosis.

Authors
Nakama-LH; King-KB; Rempel-DM
Source
Trans Annu Meet Orthop Res Soc 2005 Mar; 51:0762
NIOSHTIC No.
20033286
Abstract
Connective Tissue Growth Factor (CTGF) has recently been investigated in wound healing and scar formation studies. Its role in the pathology of tendon overuse injuries has not yet been investigated. CTGF is a cysteine-rich secretory protein and belongs to a six member family who are known to be involved in fundamental biological processes such as cell proliferation, attachment, migration, differentiation, wound healing and angiogenesis as well as in the development of several pathologic conditions including fibrosis and tumorigenesis. CTGF has been identified as a potent inducer of extracellular matrix synthesis and is up-regulated by tensile stresses. Soft tissue injuries are common in athletes and workers whose job functions require repetitive and forceful hand activities. The mechanism leading to tendinosis is not well known but likely involves microtears and an inflammatory response. The purpose of this study was to evaluate the effects of in vivo cyclical digit loading on CTGF- positive staining cell density in the Flexor Digitorum Profundus (FDP) tendon at the epicondyle.
Keywords
In-vivo-studies; Injuries; Laboratory-animals; Animal-studies; Muscles; Repetitive-work; Cumulative-trauma-disorders; Cumulative-trauma; Musculoskeletal-system; Musculoskeletal-system-disorders; Biomechanics; Laboratory-animals; Models; Tissue-disorders
Publication Date
20050301
Document Type
Abstract; Conference/Symposia Proceedings
Email Address
drempel@itsa.ucsf.edu
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007359
ISSN
0149-6433
Priority Area
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Source Name
Transactions of the Annual Meeting of the Orthopaedic Research Society
State
CA
Performing Organization
University of California - San Francisco
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