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In vivo cyclical joint loading decreases unmineralized cartilage thickness in the rabbit metacarpophalangeal.

Authors
Opel-C; Rempel-D; King-KB
Source
Trans Annu Meet Orthop Res Soc 2005 Mar; 51:1638
NIOSHTIC No.
20033285
Abstract
Understanding the mechanobiology of joint loading is essential for progress in treating osteoarthritis as well as other degenerative joint diseases and to help engineer cartilage tissue replacements. This study examines articular joint tissue changes resulting from in vivo cyclical loading in a rabbit model. This new animal model has the potential to advance our understanding of adult endochondral ossification and degenerative joint disease.
Keywords
In-vivo-studies; Injuries; Laboratory-animals; Animal-studies; Muscles; Repetitive-work; Cumulative-trauma-disorders; Cumulative-trauma; Musculoskeletal-system; Musculoskeletal-system-disorders; Biomechanics; Laboratory-animals; Models; Bone-disorders
Contact
Department of Medicine, University of California, San Francisco, CA
Publication Date
20050301
Document Type
Abstract; Conference/Symposia Proceedings
Email Address
kbking@itsa.ucsf.edu
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007359
ISSN
0149-6433
Priority Area
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Source Name
Transactions of the Annual Meeting of the Orthopaedic Research Society
State
CA
Performing Organization
University of California - San Francisco
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