Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Effect of repetition rate on blood vessel formation in the paratenon of a repetitively loaded tendon in vivo.

Authors
Nakama-LH; Amano-K; King-KB; Rempel-DM
Source
Trans Annu Meet Orthop Res Soc 2006 Mar; 52:1096
NIOSHTIC No.
20033281
Abstract
Soft tissue injuries are common in athletes and workers whose job functions require the use of repetitive high force hand activities. The exact mechanisms leading up to tendinopathy is unknown but both biomechanical and biochemical factors play a significant role. Previously Vascular Endothelial Growth Factor, VEGF, had been found in human biopsies of degenerated tendons and in cyclically strained fibroblast cell cultures (1). Recently, this protein was shown to increase with loading (2) using a repetition rate of 60 reps/min, where the highest levels were found in the outer regions of the tendon, next to the paratenon. VEGF is responsible for stimulating the proliferation of microvascular endothelial cells and inducing angiogenesis. The purpose of this study was to evaluate changes in blood vessel number in the paratenon of the FDP tendon at the epicondyle following in vivo cyclical finger loading at different repetition rates (10 versus 60 reps/min), but the same force and duty cycle using a rabbit model.
Keywords
In-vivo-studies; Models; Injuries; Laboratory-animals; Animals; Animal-studies; Muscles; Repetitive-work; Cumulative-trauma-disorders; Cumulative-trauma; Musculoskeletal-system; Musculoskeletal-system-disorders
Contact
DM Rempel, University of California, San Francisco, CA
Publication Date
20060301
Document Type
Abstract; Conference/Symposia Proceedings
Email Address
Drempel@itsa.ucsf.edu
Funding Type
Grant
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007359
ISSN
0149-6433
Priority Area
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Source Name
Transactions of the Annual Meeting of the Orthopaedic Research Society
State
CA
Performing Organization
University of California - San Francisco
TOP