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Thermoregulation and its influence on toxicity assessment.

Authors
Gordon-CJ; Spencer-PJ; Hotchkiss-J; Miller-DB; Hinderliter-PM; Pauluhn-J
Source
Toxicology 2008 Feb; 244(2-3):87-97
NIOSHTIC No.
20033266
Abstract
The thermoregulatory system of laboratory rodents is susceptible to a variety of chemical toxicants. Because temperature directly affects the reaction of virtually all biological processes, it is critical to consider how changes in the thermoregulatory response to a toxicant may affect physiological, behavioral, and pathological endpoints. Researchers in industry and government laboratories are often faced with addressing how changes in body temperature of their experimental subjects may affect the outcome of a particular toxicity test and/or screening panel. However, many toxicologists are either unaware of the importance or ignore the potential impact of a toxic-induced change in body temperature. This paper endeavors to summarize the importance of thermoregulation in the study of toxicology and propose recommendations for thermometry that researchers may utilize in their toxicological studies.
Keywords
Exposure-assessment; Laboratory-animals; Biological-monitoring; Biological-agents; Temperature-effects; Temperature-control; Behavior; Physiological-measurements; Physiological-stress; Toxicology; Toxicopathology; Work-environment; Work-areas
Contact
Christopher J. Gordon, Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, B105-04, U.S. Environmental Protection Agency, 109 S.T.W. Alexander Drive, Research Triangle Park, NC 27711
CODEN
TXCYAC
Publication Date
20080201
Document Type
Journal Article; Academic/Scholarly
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Issue of Publication
2-3
ISSN
0300-483X
NIOSH Division
HELD
Priority Area
Services
Source Name
Toxicology
State
WA; NC; MI; WV
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