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Reduced lung cell proliferation following short-term exposure to ultrafine soot and iron particles in neonatal rats: key to impaired lung growth.

Authors
Pinkerton-KE; Zhou-YM; Teague-SV; Peake-JL; Walther-RC; Kennedy-IM; Leppert-VJ; Aust-AE
Source
Inhal Toxicol 2004 Jan; 16(Suppl 1):73-81
NIOSHTIC No.
20033264
Abstract
Particulate matter (PM) has been associated with a variety of negative health outcomes in children involving the respiratory system and early development. However, the precise mechanisms to explain how exposure to airborne particles may cause adverse effects in children are unknown. To study their influence on early postnatal development, a simple, laminar diffusion flame was used to generate an aerosol of soot and iron particles in the size range of 10 to 50 nm. Exposure of 10-day-old rat pups to soot and iron particles was for 6 h/day for 3 days. The lungs were examined following a single injection of bromodeoxyuridine (BrdU) 2 h prior to necropsy. Neonatal rats exposed to these particles demonstrated no effect on the rate of cell proliferation within terminal bronchioles or the general lung parenchyma. In contrast, within those regions arising immediately beyond the terminal bronchioles (defined as the proximal alveolar region), the rate of cell proliferation was significantly reduced compared with filtered air controls. These findings strongly suggest exposure to airborne particles during early neonatal life has significant direct effects on lung growth by altering cell division within critical sites of the respiratory tract during periods of rapid postnatal development. Such effects may result in altered growth in the respiratory system that may be associated with lifelong consequences.
Keywords
Animal-studies; Animals; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Cell-alteration; Cell-biology; Cell-cultures; Cell-damage; Cell-function; Exposure-levels; Exposure-limits; Lung; Lung-burden; Lung-cells; Lung-disease; Lung-disorders; Lung-tissue; Particulate-dust; Particulates; Respiratory-irritants; Respiratory-neoplasms; Respiratory-protection; Respiratory-system-disorders; Airborne-particles; Aerosol-particles; Aerosol-sampling; Aerosols; Nanotechnology
Contact
K. E. Pinkerton, Center for Health and the Environment, and Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, California
CODEN
INHTE5
Publication Date
20040101
Document Type
Journal Article
Funding Amount
1055222
Funding Type
Cooperative Agreement
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U07-CCU-906162
ISSN
0895-8378
Source Name
Inhalation Toxicology
State
CA; UT
Performing Organization
University of California - Davis
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