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Nicotine- or epinephrine-induced uteroplacental vasoconstriction and fetal growth in the rat.

Authors
Birnbaum-SC; Kien-N; Martucci-RW; Gelzleichter-TR; Witschi-H; Hendrickx-AG; Last-JA
Source
Toxicology 1994 Nov-Dec; 94(1-3):69-80
NIOSHTIC No.
20033249
Abstract
We examined the relationship between nicotine-induced vasoconstriction in pregnant rat dams and fetal growth during the third trimester of pregnancy. Pregnant rats were continuously treated between days 13 and 19 of gestation with either nicotine (9.6, 4.8 or 2.4 mg/kg/day), epinephrine (0.72 microgram/kg/day), or saline via continuous infusion from a subcutaneously implanted osmotic minipump. Placental weights in rats treated with high dose nicotine and dams' body weights were severely reduced. However, fetal weights were not affected. Blood flows in uterus and placenta were quantified by measurement of tissue content of 85Sr-labelled microspheres injected via a carotid artery catheter. Both nicotine and epinephrine caused a significant reduction (> 40%) in uterine and placental blood flow. We conclude that vasoconstriction alone as a result of nicotine or epinephrine administration during the last trimester of gestation does not necessarily reduce nutrient supply to the fetus and does not affect fetal growth in rats.
Keywords
Animal-studies; Animals; Nerve-function; Nerve-tissue; Nerves; Fertility; Fetus; Growth-disorders; Growth-factors; Growth-inhibition; Growth-rate; Chemical-composition; Chemical-indicators; Chemical-reactions; Chemical-structure; Chemical-synthesis; Blood-analysis; Blood-gas-analysis; Blood-poisoning; Blood-samples; Blood-sampling; Urinalysis; Cigarette-smoking
Contact
S. C. Birnbaum, Department of Anesthesiology, School of Medicine, University of California, Davis 95616-8542
CODEN
TXCYAC
Publication Date
19941101
Document Type
Journal Article
Funding Amount
1055222
Funding Type
Cooperative Agreement
Fiscal Year
1995
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U07-CCU-906162
Issue of Publication
1-3
ISSN
0300-483X
Source Name
Toxicology
State
CA
Performing Organization
University of California - Davis
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