Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Alteration of estrogen-regulated gene expression in human cells induced by the agricultural and horticultural herbicide glyphosate.

Authors
Hokanson-R; Fudge-R; Chowdhary-R; Busbee-D
Source
Hum Exp Toxicol 2007 Sep; 26(9):747-752
NIOSHTIC No.
20033248
Abstract
Gene expression is altered in mammalian cells (MCF-7 cells), by exposure to a variety of chemicals that mimic steroid hormones or interact with endocrine receptors or their co-factors. Among those populations chronically exposed to these endocrine disruptive chemicals are persons, and their families, who are employed in agriculture or horticulture, or who use agricultural/horticultural chemicals. Among the chemicals most commonly used, both commercially and in the home, is the herbicide glyphosate. Although glyphosate is commonly considered to be relatively non-toxic, we utilized in vitro DNA microarray analysis of this chemical to evaluate its capacity to alter the expression of a variety of genes in human cells. We selected a group of genes, determined by DNA microarray analysis to be dysregulated, and used quantitative real-time PCR to corroborate their altered states of expression. We discussed the reported function of those genes, with emphasis on altered physiological states that are capable of initiating adverse health effects that might be anticipated if gene expression were significantly altered in either adults or embryos exposed in utero.
Keywords
Genes; Insecticides; DNA-damage; Agricultural-chemicals; Organo-phosphorus-pesticides; Pesticides-and-agricultural-chemicals; Pesticides; Genetic-disorders; Genetic-factors; Genetics; Cell-biology; Cell-differentiation; Cell-morphology; Cell-transformation; Cellular-reactions; Physiological-disorders; Physiological-effects; Physiological-response
Contact
Dr David L Busbee, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843,
CODEN
HETOEA
Publication Date
20070901
Document Type
Journal Article
Email Address
dbusbee@cvm.tamu.edu
Funding Type
Cooperative Agreement
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U50-OH-007541
Issue of Publication
9
ISSN
0960-3271
Source Name
Human and Experimental Toxicology
State
TX
Performing Organization
University of Texas Health Center at Tyler
TOP