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Computer-controlled ozone inhalation exposure system.

Authors
McKinney-W; Frazer-D
Source
Inhal Toxicol 2008 Jan; 20(1):43-48
NIOSHTIC No.
20033242
Abstract
Accurate systems designed to expose laboratory animals to carefully controlled concentrations of gases and aerosols are an important tool in inhalation toxicology studies. These systems are necessary for determining the dose-response relationship of toxicants under a variety of exposure conditions. The objective of this project was to develop a system, employing feedback control, to expose small laboratory animals to precise concentrations of ozone. This system needed the capability of maintaining exposures at selected levels between 0.2 to 3.0 ppm over specified periods ranging between 1 and 8 h in order to evaluate health risks associated with ozone. The overall goals of this study were (1) to develop a system capable of automatically controlling the ozone exposure levels so the steady-state error remained less than 1% and (2) to optimize the system's response time. By employing a tuned control algorithm, gas monitors, data acquisition, and a custom computer software program, these two goals were realized.
Keywords
Toxicology; Air-flow; Air-sampling-techniques; Laboratory-animals; Laboratory-equipment; Exposure-chambers; Exposure-methods; Inhalation-studies
CODEN
INHTE5
CAS No.
10028-15-6
Publication Date
20080101
Document Type
Journal Article
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0895-8378
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Inhalation Toxicology
State
WV
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