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Delivery methods for peptide and protein toxins in insect control.

Authors
Whetstone-PA; Hammock-BD
Source
Toxicon 2007 Mar; 49(4):576-596
NIOSHTIC No.
20033211
Abstract
Since the introduction of DDT in the 1940s, arthropod pest control has relied heavily upon chemical insecticides. However, the development of insect resistance, an increased awareness of the real and perceived environmental and health impacts of these chemicals, and the need for systems with a smaller environmental footprint has stimulated the search for new insecticidal compounds, novel molecular targets, and alternative control methods. In recent decades a variety of biocontrol methods employing peptidic or proteinaceous insect-specific toxins derived from microbes, plants and animals have been examined in the laboratory and field with varying results. Among the many interdependent factors involved with the production of a cost-effective pesticide--production expense, kill efficiency, environmental persistence, pest-specificity, pest resistance-development, public perception and ease of delivery--sprayable biopesticides have not yet found equal competitive footing with chemical counterparts. However, while protein/peptide-based biopesticides continue to have limitations, advances in the technology, particularly of genetically modified organisms as biopesticidal delivery systems, has continually progressed. This review highlights the varieties of delivery methods currently practiced, examining the strengths and weaknesses of each method.
Keywords
Pest-control; Pesticide-industry; Pesticide-residues; Pesticides; Chemical-analysis; Pests; Control-methods; Control-systems; Animal-products; Animal-studies; Animals; Environmental-control; Environmental-exposure; Environmental-factors; Environmental-hazards; Environmental-health; Environmental-pollution; Environmental-protection; Atmosphere-analyzers; Protein-biochemistry; Protein-biosynthesis; Protein-chemistry; Protein-synthesis; Proteins; Biohazards; Biological-factors; Biological-monitoring; Biological-warfare-agents; Toxic-effects; Toxic-materials; Toxic-vapors; Toxins
Contact
P. A. Whetstone, Bayer Healthcare, Quality Control Unit, Berkeley, CA 94701
CODEN
TOXIA6
Publication Date
20070315
Document Type
Journal Article
Funding Type
Agriculture; Cooperative Agreement
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U50-OH-007550
Issue of Publication
4
ISSN
0041-0101
Source Name
Toxicon
State
CA
Performing Organization
University of California - Davis
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