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Mortality among workers at the Savannah River Site.

Authors
Richardson-DB; Wing-S; Wolf-S
Source
Am J Ind Med 2007 Dec; 50(12):881-891
NIOSHTIC No.
20033198
Abstract
Background: Workers employed at the Savannah River Site (SRS) were potentially exposed to a range of chemical and physical hazards, many of which are poorly characterized.We therefore compared the observed deaths among workers to expectations based upon death rates for referent populations. Methods: The cohort included 18,883 SRS workers hired between 1950 and 1986. Vital status and cause of death information were ascertained through 2002. Sex-specific standardized mortality ratios (SMR) were computed usingU.S. and South Carolinamortality rates. SMRs were tabulated separately for monthly-, weekly-, and hourly-paid men. Results: Males had fewer deaths from all causes [SMR=0.80, 90% confidence interval (CI): 0.78, 0.82], all cancers (SMR=0.85, 90% CI: 0.81, 0.89), and lung cancer (SMR=0.88, 90%CI: 0.82, 0.95) than expected based upon US mortality rates. The SMR for cancer of the pleura was 4.25 (90% CI: 1.99, 7.97) for men. The SMR for leukemia was greater than unity for monthly-paid (SMR=1.33, 90% CI: 0.88, 1.93) and hourly-paid (SMR=1.36, 90% CI: 1.02, 1.78) men. Female workers had fewer deaths from all causes (SMR=0.75, 90%CI: 0.69, 0.82) than expected, but more deaths than expected from cancer of the kidney (SMR=2.58, 90%CI: 1.21, 4.84) and skin (SMR=3.90, 90%CI: 2.11, 6.61). Conclusions: While the observed numbers of deaths in most categories of cause of death were less than expected, there are greater than expected numbers of deaths due to cancer of the pleura and leukemia, particularly among hourly-paid male workers. It is plausible that occupational hazards, including asbestos and ionizing radiation, contribute to these excesses.
Keywords
Nuclear-power-plants; Cancer; Cancer-rates; Occupational-diseases; Mortality-data; Mortality-rates; Asbestos-dust; Ionizing-radiation; Men; Women; Epidemiology; Statistical-analysis; Region-4; Leukemogenesis; Lung-cancer; Pleural-cavity; Kidney-disorders; Skin-cancer; Nuclear-radiation; Nuclear-energy; Nuclear-hazards; Author Keywords: cohort studies; mortality study; Savannah River Site; occupational diseases
Contact
David B. Richardson, Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
CODEN
AJIMD8
Publication Date
20071201
Document Type
Journal Article
Email Address
david.richardson@unc.edu
Funding Type
Grant
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007871
Issue of Publication
12
ISSN
0271-3586
Priority Area
Research Tools and Approaches: Cancer Research Methods
Source Name
American Journal of Industrial Medicine
State
NC
Performing Organization
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
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