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Molecular and cellular biomarker responses to pesticide exposure in juvenile chinook salmon (Oncorhynchus tshawytscha).

Authors
Eder-KJ; Leutenegger-CM; Wilson-BW; Werne-I
Source
Mar Environ Res 2004 Aug-Dec; 58(2-5):809-813
NIOSHTIC No.
20033135
Abstract
We determined the effects of two pesticides, chlorpyrifos and esfenvalerate in juvenile Chinook salmon. Four to five month old salmon were exposed to a range of pesticide concentrations, and tissue samples of surviving fish were analyzed for stress protein expression, cytokine transcription, and acetylcholinesterase (AChE) activity. At the highest concentrations, both pesticides led to complete mortality, whereas medium and low concentrations resulted in high survival rates. Significant differences in stress protein expression, cytokine transcription and AChE activity were found between control and surviving chlorpyrifos-exposed fish. Elevated stress protein expression was the only detectable response to esfenvalerate.
Keywords
Pesticides; Chemical-analysis; Sea-water; Cytotoxic-effects; Cytotoxicity; Cytotoxins; Proteins; Protein-biochemistry
CODEN
MERSDW
CAS No.
2921-88-2; 66230-04-4
Publication Date
20040801
Document Type
Journal Article
Email Address
kjeder@ucdavis.edu
Funding Type
Agriculture; Cooperative Agreement
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U50-OH-007550
Issue of Publication
2-5
ISSN
0141-1136
Source Name
Marine Environmental Research
State
CA
Performing Organization
University of California - Davis
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