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Distribution of injury and microdosimetry of ozone in the ventilatory unit of the rat.

Authors
Pinkerton-KE; Mercer-RR; Plopper-CG; Crapo-JD
Source
Am J Physiol 1992 Sep; 73(3):817-824
NIOSHTIC No.
20033131
Abstract
The distribution of ozone-induced injury across ventilatory units of the lungs was determined and compared with the predicted distribution of ozone dose across the same units to evaluate dose-response relationships. Sprague-Dawley rats were exposed to either 0.98 ppm ozone 8 h/day for 90 days or to filtered air only. En bloc microdissection was used to identify and isolate in longitudinal profile the bronchiole-alveolar duct junction, first pair of alveolar duct generations, and intervening bifurcation ridge. The first alveolar outpocketing along the bronchiolar wall of each isolation was used to identify the center of a series of concentric arcs radiating outward at 100-microns intervals across each ventilatory unit. The intercept lengths of each arc with the tissue of alveolar septal tips (edges) and alveolar walls were measured and expressed as a function of distance into the ventilatory unit. Relative ozone dose across the ventilatory unit was estimated using the geometry of the tracheobronchial tree and the volume and surface area distribution within individual ventilatory units. This mathematical model of ozone dose demonstrated a high degree of correlation to this measured tissue injury response. The findings of this study demonstrate that microdosimetry and microtoxicology can be used to determine dose-response relationships within the ventilatory unit and to assess questions of tissue sensitivity in ozone-induced lung injury.
Keywords
Animal-studies; Animals; Chemical-analysis; Chemical-hypersensitivity; Chemical-indicators; Chemical-reactions; Chemical-synthesis; Ventilation; Respirators; Respiratory-function-tests; Lung; Lung-burden; Lung-disease; Lung-disorders; Lung-fibrosis; Lung-function; Lung-irritants
Contact
KE Pinkerton, Department of Anatomy, School of Veterinary Medicine, University of California, Davis 95616
CODEN
AJPHAP
Publication Date
19920901
Document Type
Journal Article
Funding Amount
1055222
Funding Type
Cooperative Agreement
Fiscal Year
1992
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U07-CCU-906162
Issue of Publication
3
ISSN
1040-0605
Source Name
American Journal of Physiology
State
CA; NC
Performing Organization
University of California - Davis
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