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Pulmonary responses of acute exposure to ultrafine iron particles in healthy adult rats.

Authors
Zhou-YM; Zhong-CY; Kennedy-IM; Pinkerton-KE
Source
Environ Toxicol 2003 Aug; 18(4):227-235
NIOSHTIC No.
20033124
Abstract
As critical constituents of ambient particulate matter, transition metals such as iron may play an important role in health outcomes associated with air pollution. The purpose of this study was to determine the respiratory effects of inhaled ultrafine iron particles in rats. Sprague Dawley rats 10-12 weeks of age were exposed by inhalation to iron particles (57 and 90 microg/m(3), respectively) or filtered air (FA) for 6 h/day for 3 days. The median diameter of particles generated was 72 nm. Exposure to iron particles at a concentration of 90 microg/m(3) resulted in a significant decrease in total antioxidant power along with a significant induction in ferritin expression, GST activity, and IL-1beta levels in lungs compared with lungs of the FA control or of animals exposed to iron particles at 57 microg/m(3). NFkappaB-DNA binding activity was elevated 1.3-fold compared with that of control animals following exposure to 90 microg/m(3) of iron, but this change was not statistically significant. We concluded that inhalation of iron particles leads to oxidative stress associated with a proinflammatory response in a dose-dependent manner. The activation of NFkappaB may be involved in iron-induced respiratory responses, but further studies are merited.
Keywords
Pulmonary-disorders; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Inhalation-studies; Particulate-dust; Particulates; Oxidation; Oxidative-metabolism; Oxidative-processes; Respiratory-function-tests; Respiratory-hypersensitivity; Respiratory-irritants; Iron-compounds; Iron-oxides; Animal-studies; Animals; Nanotechnology
Contact
YM Zhou, Center for Health and the Environment, University of California, Davis, California 95616
CODEN
ETOXFH
Publication Date
20030801
Document Type
Journal Article
Email Address
kepinkerton@ucdavis.edu
Funding Amount
1055222
Funding Type
Cooperative Agreement
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U07-CCU-906162
Issue of Publication
4
ISSN
1520-4081
Source Name
Environmental Toxicology
State
CA
Performing Organization
University of California - Davis
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