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Inflammation and lung cancer: roles of reactive oxygen/nitrogen species.

Authors
Azad-N; Rojanasakul-Y; Vallyathan-V
Source
J Toxicol Environ Health, B 2008 Jan; 11(1):1-15
NIOSHTIC No.
20033081
Abstract
The lung is a highly specialized organ that facilitates uptake of oxygen and release of carbon dioxide. Due to its unique structure providing enormous surface area to outside ambient air, it is vulnerable to numerous pathogens, pollutants, oxidants, gases, and toxicants that are inhaled continuously from air, which makes the lung susceptible to varying degrees of oxidative injury. To combat these unrelenting physical, chemical, and biological insults, the respiratory epithelium is covered with a thin layer of lining fluid containing several antioxidants and surfactants. Inhaled toxic agents stimulate the generation of reactive oxygen/nitrogen species (ROS/RNS), which in turn provoke inflammatory responses resulting in the release of proinflammatory cytokines and chemokines. These subsequently stimulate the influx of polymorphonuclear leukocytes (PMNs) and monocytes into the lung so as to combat the invading pathogens or toxic agents. In addition to the beneficial effects, persistent inhalation of the invading pathogens or toxic agents may result in overwhelming production of ROS/RNS, producing chronic inflammation and lung injury. During inflammation, enhanced ROS/RNS production may induce recurring DNA damage, inhibition of apoptosis, and activation of proto-oncogenes by initiating signal transduction pathways. Therefore, it is conceivable that chronic inflammation-induced production of ROS/RNS in the lung may predispose individuals to lung cancer. This review describes the complex relationship between lung inflammation and carcinogenesis, and highlights the role of ROS/RNS in cancer development.
Keywords
Exposure-levels; Exposure-assessment; Occupational-exposure; Pulmonary-system-disorders; Respiratory-system-disorders; Lung-cells; Lung-disorders; Lung-function; Lung-irritants; Lung-cancer; Cell-biology; Cell-function
Contact
Val Vallyathan, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
CODEN
JTECFR
Publication Date
20080101
Document Type
Journal Article; Academic/Scholarly
Email Address
vav1@cdc.gov
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
1093-7404
NIOSH Division
HELD
Priority Area
Manufacturing; Mining
Source Name
Journal of Toxicology and Environmental Health, Part B: Critical Reviews
State
WV
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