Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

A Shope Fibroma virus PYRIN-only protein modulates the host immune response.

Authors
Dorfleutner-A; Talbott-SJ; Bryan-NB; Funya-KN; Rellick-SL; Reed-JC; Shi-X; Rojanasakul-Y; Flynn-DC; Stehlik-C
Source
Virus Genes 2007 Dec; 35(3):685-694
NIOSHTIC No.
20033020
Abstract
PYRIN domain (PYD) proteins have recently emerged as important signaling molecules involved in the development of innate immunity to intracellular pathogens through activation of inflammatory mediator pathways. ASC is the central adaptor protein, which links pathogen recognition by PYD-containing pathogen recognition receptors to the activation of downstream effectors, including activation of Caspase-1 and NF-kappa B. The cellular PYD-only protein 1 (cPOP1) can block the recruitment of ASC to activated PAN receptors and thereby functions as an endogenous inhibitor of the PYD-mediated signal transduction pathway. Here we describe the identification and characterization of a Shope Fibroma homolog to cPOP1. Like cPOP1, a Shope Fibroma virus-encoded POP (vPOP), co-localizes and directly associates with ASC and inhibits PYD-mediated signal transduction. Poxviruses are known to encode immune evasive proteins to promote host cell infection and suppression of the host immune response. Poxvirus-encoded vPOPs represent a novel class of immune evasive proteins and impair the host response by blocking Cryopyrin and ASC inflammasome-mediated activation of pro-Caspase-1 and subsequent processing of pro-interleukin (IL)-1 beta, and expression of vPOPs causes activation of NF-kappa B.
Keywords
Genetics; Viral-diseases; Viral-infections; Cell-biology; Cell-cultures; Cell-metabolism; Cellular-reactions; Immune-system-disorders; Immune-system; Immunologic-disorders
Contact
Christian Stehlik, Mary Babb Randolph Cancer Center and Department of Microbiology, Immunology & Cell Biology, West Virginia University School of Medicine, 1826 MBRCC, 1 Medical Center Drive, Morgantown, WV 26506-9300
CODEN
VIGEET
Publication Date
20071201
Document Type
Journal Article
Email Address
cstehlik@hsc.wvu.edu
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0920-8569
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Virus Genes
State
WV
TOP