Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Leukemia mortality among workers at the Savannah River Site.

Authors
Richardson-DB; Wing-S
Source
Am J Epidemiol 2007 Nov; 166(9):1015-1022
NIOSHTIC No.
20032997
Abstract
The authors investigated associations between ionizing radiation and leukemia mortality among workers at the Savannah River Site (South Carolina). A total of 18,883 workers hired between 1950 and 1986 were followed through 2002 to ascertain causes of death. Estimates of radiation doses from external sources and internal tritium uptakes were derived from dosimetry records through 1999. Radiation dose-mortality trends were evaluated for leukemia, leukemia excluding chronic lymphocytic leukemia, and myeloid leukemia. A positive association was observed between leukemia mortality and radiation dose under a 3-year lag assumption (excess relative rate/10 mSv = 0.04, 90% confidence interval: -0.00, 0.12). The association was of larger magnitude for leukemia excluding chronic lymphocytic leukemia (excess relative rate/10 mSv = 0.08, 90% confidence interval: 0.01, 0.20) and myeloid leukemia (excess relative rate/10 mSv = 0.12, 90% confidence interval: 0.02, 0.35). Compared with males, females had less complete dosimetry information; when analyses were restricted to males, the estimated association for each cause of death increased slightly in magnitude and goodness of fit. Exposures accrued 3-15 years prior were more strongly related to leukemia than exposures in the more distant past. This study provides evidence of positive associations between radiation dose and leukemia mortality among Savannah River Site workers. The temporal patterns of association appear consistent with those in studies of populations exposed at higher dose rates.
Keywords
Mortality-data; Mortality-rates; Cancer; Cancer-rates; Epidemiology; Radiation-therapy; Lymphocytes; Lymphatic-cancer; Lymphatic-system-disorders; Statistical-analysis; Radiation-effects; Radiation-exposure; Radiation-hazards; Radiation-injury; Radiation-monitoring; Radiation-sources; Radiation-tolerance; Author Keywords: leukemia; mortality; nuclear energy; ionizing radiation; South Carolina
Contact
David B. Richardson, Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7435
CODEN
AJEPAS
Publication Date
20071101
Document Type
Journal Article
Email Address
david.richardson@unc.edu
Funding Type
Grant
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007871
Issue of Publication
9
ISSN
0002-9262
Priority Area
Research Tools and Approaches: Cancer Research Methods
Source Name
American Journal of Epidemiology
State
NC
Performing Organization
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
TOP