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Nuclear factor-kB, an unappreciated tumor suppressor.

Authors
Chen-F; Castranova-V
Source
Cancer Res 2007 Dec; 67(23):11093-11098
NIOSHTIC No.
20032960
Abstract
The notion that nuclear factor-B (NF-B) is a tumor-promoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-B in carcinogenesis and tumorigenesis. Although the tumor suppressor-like effect of NF-B remains to be rigorously established by further studies using cellular and animal models, these latest findings warrant caution with respect to blockage of NF-B activation as a broad strategy in treating cancers.
Keywords
Nuclear-medicine; Cancer; Cell-morphology; Cell-biology; Cancer; Animal-studies
Contact
Fei Chen, The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
CNREA8
Publication Date
20071201
Document Type
Journal Article
Email Address
fchen@cdc.gov
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Issue of Publication
23
ISSN
0008-5472
NIOSH Division
HELD
Priority Area
Manufacturing; Mining
Source Name
Cancer Research
State
WV
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