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Characterization of internal exposure to enriched uranium at a former gaseous diffusion plant.

Authors
Anderson-JL; Spitz-HB; Yiin-JH
Source
Health Phys 2007 Dec; 93(6):636-644
NIOSHTIC No.
20032957
Abstract
The National Institute for Occupational Safety and Health (NIOSH) is conducting a nested case-control study of mortality from multiple myeloma involving 581 subjects who worked at the Oak Ridge K-25 Gaseous Diffusion Plant. Internally-deposited uranium is the primary agent being considered in the exposure assessment. Routine operation and maintenance of the plant presented the potential for inhaling uranium of various enrichments. As part of the exposure assessment, records describing the various plant processes and procedures, documentation on the medical monitoring program, uranium urinalysis data, and procedures and analytical methods for monitoring uranium exposure were retrieved and reviewed. Uranium urinalysis data consisted of 161,055 uranium urinalysis results obtained by fluorometry and 171,914 results obtained by alpha particle counting. Approximately 20% of the workers were monitored for internal exposure using urine sampling. Mean and median uranium concentrations in urine for the monitored study subjects were slightly lower than for the entire population of monitored K-25 workers. The specific activity of uranium excreted in urine was determined by comparing results obtained using fluorometric and alpha activity measurements and indicate that the majority of internal exposure involved uranium that was depleted or enriched to no more than 4% 235U.
Keywords
Statistical-analysis; Mortality-rates; Mortality-surveys; Uranium-compounds; Inhalation-studies; Work-environment; Medical-monitoring; Particle-counters; Particle-aerodynamics; Urinalysis; Urine-chemistry; Bioassays
Contact
Jeri L. Anderson, NIOSH, DSHEFS, 5555 Ridge Avenue, R-44, Cincinnati, OH 45213
CODEN
HLTPAO
Publication Date
20071201
Document Type
Journal Article
Email Address
JLAnderson@cdc.gov
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
0017-9078
NIOSH Division
DSHEFS
Source Name
Health Physics
State
OH
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