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Paraoxonase 1 (PON1) status and risk of insecticide exposure.

Authors
Furlong-CR; Cole-TB; Walter-BJ; Shih-DM; Tward-A; Lusis-AJ; Timchalk-C; Richter-RJ; Costa-LG
Source
J Biochem Mol Toxicol 2005 Apr; 19(3):182-183
NIOSHTIC No.
20032920
Abstract
Paraoxonase 1 (PON1) is an HDL associated enzyme that catalyzes a number of different reactions including the hydrolysis of the toxic oxon metabolites of the insecticides diazinon and chlorpyrifos. PON1 has also been implicated in the detoxication of oxidized lipids and the metabolism of a number of drugs, activating some, while inactivating others. There are two common PON1 coding region polymorphisms (L55M and Q192R). The latter determines the catalytic efficiency of hydrolysis of a number of substrates including chlorpyrifos oxon, but not diazoxon. Evidence for the physiological importance ofPON1 in modulating exposures to these two insecticides comes from several different studies. Early studies noted that species with high levels of PON1 were much more resistant to certain organophosphorus (OP) insecticides than were species with low levels. Another early study by Main demonstrated that injected rabbit paraoxonase protected rats from paraoxon toxicity. Our research group began the development of a mouse model system for examining the importance of PON1 in the detoxication of OP insecticides.
Keywords
Organo-phosphorus-compounds; Organo-phosphorus-pesticides; Pesticides; In-vitro-studies; Models; Environmental-factors; Insecticide-poisoning; Quantitative-analysis; Laboratory-animals; Brain-function; Brain-electrical-activity; Cerebrovascular-system-disorders; Animals
Contact
Clement E. Furlong, Department of Medicine, Division of Medical Genetics, University of Washington, Seattle,WA 98195-7720
CODEN
JBMTFQ
Publication Date
20050401
Document Type
Journal Article
Email Address
clem@u.washington.edu
Funding Amount
246279
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003629
Issue of Publication
3
ISSN
1095-6670
Priority Area
Research Tools and Approaches: Exposure Assessment Methods
Source Name
Journal of Biochemical and Molecular Toxicology
State
WA; CA
Performing Organization
Battelle Memorial Institute, Richland, Washington
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