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Risk factors for symptom onset in PI*Z alpha-1 antitrypsin deficiency.

Authors
Mayer-AS; Stoller-JK; Vedal-S; Ruttenber-AJ; Strand-M; Sandhaus-RA; Newman-LS
Source
Int J Chron Obstruct Pulmon Dis 2006 Dec; 1(4):485-492
NIOSHTIC No.
20032906
Abstract
BACKGROUND: In an early study of highly symptomatic patients with PI*Z alpha-1 antitrypsin deficiency (AAT), tobacco smoking was identified as a risk factor by comparing the age of symptom onset in smokers and nonsmokers. Age of symptom onset has not been well studied in relationship to other environmental exposures. METHODS: Environmental exposures were assessed in 313 PI*Z adults through retrospective self-administered questionnaire. Age of onset of symptoms with and without these exposures were analyzed through survival analysis. RESULTS: Personal smoking was the most important risk factor, associated with earlier onset of cough and wheeze, and showed a dose-dependent relationship with the onset of dyspnea. Childhood environmental tobacco smoke (ETS) exposure was independently associated with younger age of onset of cough. Earlier onset of wheeze was also associated with childhood respiratory infections and family history of emphysema. The report of childhood respiratory infections was associated with childhood ETS exposure, but no statistically significant interactions were noted. CONCLUSIONS: We conclude that both personal and secondhand exposure to tobacco smoke in childhood are likely to accelerate the onset of symptoms in AAT deficient patients. Respiratory infections in childhood may also contribute to this risk.
Keywords
Smoking; Environmental-factors; Environmental-exposure; Environmental-hazards; Age-factors; Questionnaires; Risk-analysis; Risk-factors; Respiratory-hypersensitivity; Respiratory-infections; Respiratory-irritants; Respiratory-system-disorders; Breathing; Statistical-analysis; Pulmonary-disorders; Pulmonary-function; Pulmonary-system-disorders; Tobacco-smoke
Contact
Annyce S Mayer National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206
Publication Date
20061201
Document Type
Journal Article
Email Address
mayera@njc.org
Funding Type
Grant
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R03-OH-007454
Issue of Publication
4
ISSN
1176-9106
Source Name
The International Journal of Chronic Obstructive Pulmonary Disease
State
CO
Performing Organization
National Jewish Medical and Research Center
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