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Meeting report: hazard assessment for nanoparticles - report from an interdisciplinary workshop.

Authors
Balbus-JM; Maynard-AD; Colvin-VL; Castranova-V; Daston-GP; Denison-RA; Dreher-KL; Goering-PL; Goldberg-AM; Kulinowski-KM; Monteiro-Riviere-NA; Oberdörster-G; Omenn-GS; Pinkerton-KE; Ramos-KS; Rest-KM; Sass-JB; Silbergeld-EK; Wong-BA
Source
Environ Health Perspect 2007 Nov; 115(11):1654-1659
NIOSHTIC No.
20032878
Abstract
In this report we present the findings from a nanotoxicology workshop held 6-7 April 2006 at the Woodrow Wilson International Center for Scholars in Washington, DC. Over 2 days, 26 scientists from government, academia, industry, and nonprofit organizations addressed two specific questions: what information is needed to understand the human health impact of engineered nanoparticles and how is this information best obtained? To assess hazards of nanoparticles in the near-term, most participants noted the need to use existing in vivo toxicologic tests because of their greater familiarity and interpretability. For all types of toxicology tests, the best measures of nanoparticle dose need to be determined. Most participants agreed that a standard set of nanoparticles should be validated by laboratories worldwide and made available for benchmarking tests of other newly created nanoparticles. The group concluded that a battery of tests should be developed to uncover particularly hazardous properties. Given the large number of diverse materials, most participants favored a tiered approach. Over the long term, research aimed at developing a mechanistic understanding of the numerous characteristics that influence nanoparticle toxicity was deemed essential. Predicting the potential toxicity of emerging nanoparticles will require hypothesis-driven research that elucidates how physicochemical parameters influence toxic effects on biological systems. Research needs should be determined in the context of the current availability of testing methods for nanoscale particles. Finally, the group identified general policy and strategic opportunities to accelerate the development and implementation of testing protocols and ensure that the information generated is translated effectively for all stakeholders.
Keywords
Pulmonary-system; Lung-function; Respirable-dust; Particulate-dust; Particulates; Time-weighted-average-exposure; Toxic-effects; Toxicology; Biological-effects; Biological-systems; Nanotechnology
Contact
J.M. Balbus, Environmental Defense, 1875 Connecticut Ave. NW, #600, Washington, DC 20009
CODEN
EVHPAZ
Publication Date
20071101
Document Type
Journal Article
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Issue of Publication
11
ISSN
0091-6765
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Environmental Health Perspectives
State
WV; DC; TX; OH; NC; MD; MI; NY; CA; KY; MA
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