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Pulmonary function and exercise-associated changes with chronic low-level paraquat exposure.

Authors
Schenker-MB; Stoecklin-M; Lee-K; Lupercio-R; Zeballos-RJ; Enright-P; Hennessy-T; Beckett-LA
Source
Am J Respir Crit Care Med 2004 Oct; 170(7):773-779
NIOSHTIC No.
20032829
Abstract
The present study was undertaken to test the hypothesis that chronic, low-level paraquat exposure causes restrictive lung function with gas transfer impairment. Three hundred thirty-eight Costa Rican farm workers from banana, coffee, and palm oil farms completed a questionnaire, spirometry, and a test of single-breath carbon monoxide diffusing capacity. Subjects 40 years of age or older, without other medical risk factors, completed maximal cardiopulmonary exercise tests. Most (66.6%) were paraquat handlers; 24.8% of handlers and 27.3% of nonhandlers reported current cigarette smoking. In linear regression models, cumulative paraquat exposure was not an independent predictor of VA, carbon monoxide diffusing capacity, peak oxygen uptake, FVC, or oxygen pulse peak. However, the ventilatory equivalent for CO(2), although within normal range, was significantly higher with increased cumulative paraquat exposure. Oxygen desaturation greater than 5% from rest to peak exercise had an odds ratio of 1.7 (95% confidence interval = 0.9-3.0) with the cumulative paraquat exposure index in models adjusted for age, weight, and smoking status. The association of paraquat exposure with ventilatory equivalent and oxygen desaturation suggests that paraquat may be associated with subclinical gas exchange abnormalities, but overall these findings are consistent with no clinically significant increases in interstitial thickening or restrictive lung disease among this population.
Keywords
Humans; Agricultural-chemicals; Agricultural-workers; Agricultural-industry; Agriculture; Respiratory-system-disorders; Pulmonary-system-disorders; Farmers; Questionnaires; Statistical-analysis; Epidemiology; Pesticides; Pesticides-and-agricultural-chemicals
Contact
Marc B. Schenker, M.D., M.P.H., University of California, Davis, Department of Epidemiology and Preventive Medicine, One Shields Avenue, TB168, Davis, CA 95616
CODEN
AJCMED
CAS No.
1910-42-5
Publication Date
20041001
Document Type
Journal Article
Email Address
mbschenker@ucdavis.edu
Funding Amount
1055222
Funding Type
Cooperative Agreement; Agriculture
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U07-CCU-906162
Issue of Publication
7
ISSN
1073-449X
NIOSH Division
DRDS; OD
Source Name
American Journal of Respiratory and Critical Care Medicine
State
CA; MA; NC
Performing Organization
University of California - Davis
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