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In utero exposure to DDT and performance on the Brazelton neonatal behavioral assessment scale.

Authors
Fenster-L; Eskenazi-B; Anderson-M; Bradman-A; Hubbard-A; Barr-DB
Source
Neurotoxicology 2007 May; 28(3):471-477
NIOSHTIC No.
20032781
Abstract
We investigated whether decrements in neonatal neurodevelopment, as determined by the Brazelton neonatal behavioral assessment scale (BNBAS), were associated with in utero exposure to dichlorodiphenyltrichloroethane (DDT): p,p'-dichlorodiphenyl trichloroethane (p,p'-DDT), o,p'-dichlorodiphenyl trichloroethane (o,p'-DDT) and p,p'-DDT's primary breakdown product p,p'-dichlorodiphenyl dichloroethylene (p,p'-DDE) (heretofore collectively referred to as DDT/DDE). Our subjects were a birth cohort of 303 infants whose mothers were low-income Latinas living in the Salinas Valley, an agricultural community in California. We assessed neonates < or =2 months old using the seven BNBAS clusters (habituation, orientation, motor performance, range of state, regulation of state, autonomic stability, and reflex) and examined performance in relationship to DDT/DDE measures in maternal serum samples collected during pregnancy. We did not find any detrimental associations between in utero DDT/DDE levels and neonatal performance on the BNBAS. In this same cohort, we previously demonstrated that exposures to DDT/DDE were related to decrements in neurodevelopment at 6-24 months of age. The failure to observe effects on the BNBAS in these same children may be due to limited sensitivity of a single BNBAS assessment or a delay in the manifestations of neurodevelopmental effects of DDT/DDE until after the neonatal period.
Keywords
Pregnancy; Prenatal-exposure; Risk-factors; Risk-analysis; Exposure-levels; Exposure-assessment; Biological-monitoring; Health-hazards; Agriculture; Agricultural-chemicals; Children; Sensitivity-testing; Neurological-system
Contact
Laura Fenster, California Department of Health Services, Division of Environmental and Occupational Disease Control, 850 Marina Bay Parkway, Richmond, CA 94804-6403
CODEN
NRTXDN
CAS No.
11097-69-1
Publication Date
20070501
Document Type
Journal Article
Email Address
lfenster@dhs.ca.gov
Funding Amount
909365
Funding Type
Grant
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007400
Issue of Publication
3
ISSN
0161-813X
Source Name
Neurotoxicology
State
CA; GA
Performing Organization
University of California, Berkeley
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