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Modulation of tumor development by butylated hydroxytoluene in experimental animals.

Authors
Witschi-H
Source
Toxicol Ind Health 1993 Jan-Apr; 9(1-2):259-281
NIOSHTIC No.
20032753
Abstract
The available data on the tumor-modulating effects of BHT in a variety of tissues and organs of rats and mice are analyzed. Examples were found for both tumor enhancement by BIIT and for an inhibitory action of the antioxidant on tumor formation. A total of 33 papers describing such an effect were examined. Selection was limited to papers where BHT was administered to experimental animals in the diet; all other routes of exposure were excluded. Accordingly, the bulk of available data on tumor promotion in mouse lung by BHT was ignored in the present analysis, although this particular system offers the most insight into possible mechanisms (Malkinson, 1989; Witschi et al., 1989).
Keywords
Chemical-indicators; Chemical-properties; Chemical-synthesis; Carcinogenicity; Carcinomas; Hepatocytes; Hepatotoxicity; Hepatotoxins; Laboratory-animals; Animal-studies; Liver-disorders; Liver-damage; Liver-cancer; Dose-response
Contact
Hanspeter Witschi: ITEH, University of CA, Davis, CA 95616
CODEN
TIHEEC
CAS No.
128-37-0
Publication Date
19930101
Document Type
Journal Article
Funding Amount
1055222
Funding Type
Cooperative Agreement
Fiscal Year
1993
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U07-CCU-906162
Issue of Publication
1-2
ISSN
0748-2337
Source Name
Toxicology and Industrial Health
State
CA
Performing Organization
University of California - Davis
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