Modulation of tumor development by butylated hydroxytoluene in experimental animals.
Toxicol Ind Health 1993 Jan-Apr; 9(1-2):259-281
The available data on the tumor-modulating effects of BHT in a variety of tissues and organs of rats and mice are analyzed. Examples were found for both tumor enhancement by BIIT and for an inhibitory action of the antioxidant on tumor formation. A total of 33 papers describing such an effect were examined. Selection was limited to papers where BHT was administered to experimental animals in the diet; all other routes of exposure were excluded. Accordingly, the bulk of available data on tumor promotion in mouse lung by BHT was ignored in the present analysis, although this particular system offers the most insight into possible mechanisms (Malkinson, 1989; Witschi et al., 1989).
Chemical-indicators; Chemical-properties; Chemical-synthesis; Carcinogenicity; Carcinomas; Hepatocytes; Hepatotoxicity; Hepatotoxins; Laboratory-animals; Animal-studies; Liver-disorders; Liver-damage; Liver-cancer; Dose-response
Hanspeter Witschi: ITEH, University of CA, Davis, CA 95616
Toxicology and Industrial Health
University of California - Davis