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Apoferritin-templated synthesis of encoded metallic phosphate nanoparticle tags.

Authors
Liu-G; Wu-H; Dohnalkova-A; Lin-Y
Source
Anal Chem 2007 Aug; 79(15):5614-5619
NIOSHTIC No.
20032680
Abstract
Encoded metallic phosphate nanoparticle tags, with distinct encoding patterns, have been prepared using an apoferritin template. A center cavity structure as well as the dissociation and reconstructive characteristics of apoferritin at different pH environments provides a facile route for preparing such encoded nanoparticle tags. Encapsulation and diffusion approaches have been investigated during the preparation. The encapsulation approach, which is based on the dissociation and reconstruction of apoferritin at different pHs, exhibits an effective route to prepare such encoded metallic phosphate nanoparticle tags. The compositionally encoded nanoparticle tag leads to a high coding capacity with a large number of distinguishable voltammetric signals, reflecting the predetermined composition of the metal mixture solution (and hence the nanoparticle composition). Releasing the metal components from the nanoparticle tags at pH 4.6 acetate buffer avoids harsh dissolution conditions, such as strong acids. Such a synthesis of encoded nanoparticle tags, including single-component and compositionally encoded nanoparticle tags, is substantially simple, fast, and convenient compared to that of encoded metal nanowires and semiconductor nanoparticle (CdS, PbS, and ZnS) incorporated polystyrene beads. The encoded metallic phosphate nanoparticle tags thus show great promise for bioanalytical or product-tracking/identification/protection applications.
Keywords
Particulate-sampling-methods; Metal-dusts; Metallic-dusts; Biological-effects; Nanotechnology
CODEN
ANCHAM
Publication Date
20070801
Document Type
Journal Article
Email Address
yuehe.lin@pnl.gov
Funding Type
Grant
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008173
Issue of Publication
15
ISSN
0003-2700
Priority Area
Agriculture, Forestry and Fishing
Source Name
Analytical Chemistry
State
WA
Performing Organization
Battelle Pacific Northwest Laboratories
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