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Pesticide urinary metabolite levels of children in eastern North Carolina farmworker households.

Authors
Arcury-TA; Grzywacz-JG; Barr-DB; Tapia-J; Chen-H; Quandt-SA
Source
Environ Health Perspect 2007 Aug; 115(8):1254-1260
NIOSHTIC No.
20032679
Abstract
BACKGROUND: In this investigation we documented the pesticide urinary metabolite levels of farmworker children in North Carolina, determined the number of different metabolites detected for each child, and delineated risk factors associated with the number of metabolites. METHODS: Urine samples were collected from 60 Latino farmworker children 1-6 years of age (34 female, 26 male). Interviews were completed by their mothers in Spanish. We analyzed urine samples for 14 pesticide metabolites, including the organophosphate pesticides chlorpyrifos, coumaphos, diazinon, isazaphos, malathion, pirimiphos, and parathion and its methyl counterpart; a common metabolite of at least 18 pyrethroid insecticides; the repellent DEET; and the herbicides 2,4,5-trichlorphenoxyacetic acid, 2,4-dichlorophenoxyacetic acid, acetochlor, atrazine, and metolachlor. Predictors included measures of paraoccupational, residential, and environmental exposure, child characteristics, and mother characteristics. RESULTS: Thirteen metabolites were present in the urine samples. Organophosphate pesticide metabolites were detected in a substantial proportion of children, particularly metabolites of parathion/methyl parathion (90.0%; geometric mean 1.00 microg/L), chlorpyrifos/chlorpyrifos methyl (83.3%; geometric mean 1.92 microg/L), and diazinon (55.0%; geometric mean 10.56 microg/L). The number of metabolites detected ranged from 0 to 7, with a mode of 4 detected (28.3%). Boys, children living in rented housing, and children with mothers working part-time had more metabolites detected. CONCLUSIONS: Children in farmworker homes experience multiple sources of pesticide exposure. Pesticides may remain in their environments for long periods. Environmental and occupational health changes are needed to address these exposures. Research is needed with more precise measures of exposure and on the health effects of concurrent exposure to multiple pesticides.
Keywords
Pesticides; Pesticides-and-agricultural-chemicals; Agriculture; Agricultural-industry; Agricultural-workers; Agricultural-chemicals; Occupational-exposure; Occupational-health; Environmental-health; Risk-factors; Risk-analysis; Farmers; Education; Children; Age-groups; Urinalysis; Urine-chemistry; Environmental-exposure; Environmental-factors; Metabolites
Contact
Thomas A. Arcury, Department of Family and Community Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1084
CODEN
EVHPAZ
Publication Date
20070801
Document Type
Journal Article
Email Address
tarcury@wfubmc.edu
Funding Type
Grant
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R25-OH-007611
Issue of Publication
8
ISSN
0091-6765
Source Name
Environmental Health Perspectives
State
NC
Performing Organization
Wake Forest University
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