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Non-malignant respiratory diseases and lung cancer among Chinese workers exposed to silica.

Authors
Cocco-P; Rice-CH; Chen-JQQ; McCawley-M; McLaughlin-JK; Dosemeci-M
Source
J Occup Environ Med 2000 Jun; 42(6):639-644
NIOSHTIC No.
20032669
Abstract
The objective of this study was to explore whether a medical history for non-malignant respiratory disease contributes to an increased lung cancer risk among workers exposed to silica. We analyzed data from a nested case-control study in 29 dusty workplaces in China. The study population consisted of 316 lung cancer cases and 1356 controls matched to cases by facility type and decade of birth who were alive at the time of diagnosis of the index case and who were identified in a follow-up study of about 68, 000 workers. Age at first exposure and cigarette smoking were accounted for in the analysis, Smoking was the main risk factor for both lung cancer and chronic bronchitis. Lung cancer risk showed a modest association with silicosis and with cumulative silica exposure, which did not vary by history of previous pulmonary tuberculosis. Among subjects without a medical history for chronic bronchitis or asthma, lung cancer risk was associated with silicosis (odds ratio [OR] 1.6; 95% confidence interval [CI] 1.1 to 2.2), and it was increased in each quartile of cumulative silica exposure However, risk was not elevated in the highest quartile (OR, 1.3 1.6, 1.8, 1.4). Among subjects with a medical history for chronic bronchitis or asthma, lung cancer risk was associated with neither silicosis (subjects with chronic bronchitis: OR, 0.6; subjects with asthma: OR, 0.4) nor with silica exposure. In this Study population, we observed a modest association of both silicosis and cumulative exposure to silica with lung cancer among subjects who were not previously diagnosed with chronic bronchitis or asthm, but not among subjects who had a medical history for either disease. Risk of lung cancer associated with silicosis or cumulative exposure to silica did not vary by previous medical history of pulmonary tuberculosis.
Keywords
Silica-dusts; Miners; Work-environment; Carcinogens; Mining-industry; Lung-cancer; Lung-disease; Lung-disorders; Lung-fibrosis; Pulmonary-system-disorders; Respiratory-system-disorders; Epidemiology; Statistical-analysis; Metal-dusts; Metals; Respirable-dust; Dusts; Dust-exposure; Aerosols
Contact
M Dosemeci, NCI, Occupat Epidemiol Branch, 6120 Execut Blvd,EPS Room 8002, Bethesda, MD 20892
CODEN
JOEMFM
CAS No.
7440-02-0
Publication Date
20000601
Document Type
Journal Article
Fiscal Year
2000
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
1076-2752
NIOSH Division
HELD
Source Name
Journal of Occupational and Environmental Medicine
State
WV; MD; OH
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