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NeuroAIDS, drug abuse, and inflammation: building collaborative research activities.

Authors
Berman-JW; Carson-MJ; Chang-L; Cox-BM; Fox-HS; Gonzalez-RG; Hanson-GR; Hauser-KF; Ho-W-Z; Hong-J-S; Major-EO; Maragos-WF; Masliah-E; McArthur-JC; Miller-DB; Nath-A; O'Callaghan-JP; Persidsky-Y; Power-C; Rogers-TJ; Royal-W III
Source
J Neuroimmune Pharm 2006 Dec; 1(4):351-399
NIOSHTIC No.
20032581
Abstract
Neurological complications of human immunodeficiency virus (HIV) infection are a public health problem despite the availability of active antiretroviral therapies. The neuropathogenesis of HIV infection revolves around a complex cascade of events that include viral infection and glial immune activation, monocyte-macrophage brain infiltration, and secretion of a host of viral and cellular inflammatory and neurotoxic molecules. Although there is evidence that HIV-infected drug abusers experience more severe neurological disease, the biological basis for this finding is unknown. A scientific workshop organized by the National Institute on Drug Abuse (NIDA) was held on March 23-24, 2006 to address this question. The goal of the meeting was to bring together basic science and clinical researchers who are experts in NeuroAIDS, glial immunity, drugs of abuse, and/or pharmacology in order to find new approaches to understanding interactions between drug abuse and neuroAIDS. The format of the meeting was designed to stimulate open discussion and forge new multidisciplinary research collaborations. This report includes transcripts of active discussions and short presentations from invited participants. The presentations were separated into sections that included: Glial Biology, Inflammation, and HIV; Pharmacology, Neurotoxicology, and Neuroprotection; NeuroAIDS and Virology; and Virus-Drug and Immune-Drug Interactions. Research priorities were identified.
Keywords
Biodynamics; Cell-function; Cell-metabolism; Neuropharmacology; Neurophysiology; Neuropathy; Pharmaceuticals; Pharmacodynamics; Pharmacology; Drug-abuse; Drug-receptor; Drug-interaction; Immune-system-disorders; Immunodiagnosis; Immune-reaction; Immune-system; Immunology; Neurotoxicology; Viral-infections; Central-nervous-system-disorders
Contact
Joan W. Berman, Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461
Publication Date
20061201
Document Type
Journal Article
Email Address
berman@aecom.yu.edu
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
1557-1890
NIOSH Division
HELD
Source Name
Journal of Neuroimmune Pharmacology
State
NY; CA; MD; HI; MA; UT; KY; PA; NC; WV; NE
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