Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Global patterns of gene expression following inhalation of toluene diisocyanate suggest development of allergic rhinitis.

Authors
Johnson-VJ; Kashon-ML; Yucesoy-B; Luster-MI
Source
J Immunol 2007 Aug; 178:S19a
NIOSHTIC No.
20032578
Abstract
Rhinitis is often a comorbid and preceding disease in workers afflicted with toluene diisocyanate (TDI) asthma. We hypothesized that TDI rhinitis is driven by an allergic immune response rather than innate inflammation. Global patterns of gene expression were examined via microarray in a murine model of TDI rhinitis and compared to acute nasal exposure to lipopolysaccharide (LPS). Histological analysis showed extensive inflammation of the nasal mucosa with eosinophils and neutrophils dominating in the TDI and LPS models, respectively. Effector cell recruitment correlated with expression of chemokines directed towards eosinophils in TDI rhinitis and neutrophils in LPS rhinitis. Genes involved in antigen processing/presentation, lymphocyte activation/regulation, cytokine-receptor signaling and humoral immunity were differentially regulated in TDI rhinitis. In contrast, inflammatory, innate immune and defense responses as well as response to pathogens/biotics were over represented in LPS rhinitis. These results indicate that exposure to TDI results in an antigen-driven immune response in the nasal mucosa suggestive of allergic rhinitis.
Keywords
Bronchial-asthma; Respiratory-system-disorders; Pulmonary-system-disorders; Models; Nasal-disorders; Genes; Genetic-factors; Antibody-response; Biodynamics
Contact
Dr. Victor J. Johnson, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mail Stop 3014, Morgantown, WV 26505-2888
CODEN
JOIMA3
CAS No.
584-84-9
Publication Date
20070801
Document Type
Journal Article
Email Address
vjohnson3@cdc.gov
Fiscal Year
2007
NTIS Accession No.
NTIS Price
ISSN
0022-1767
NIOSH Division
HELD
Source Name
The Journal of Immunology
State
WV
TOP