Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Acute vibration exposure reduces nitric oxide (NO) concentrations and NO-mediated vasodilation.

Authors
Krajnak-K; Waugh-S; Johnson-C; Miller-R
Source
11th International Conference on Hand-Arm-Vibration, June 3-7, 2007, Bologna, Italy. Bovenzi M, Peretti A, Nataletti P, Moschioni-G, eds., Bologna, Italy: Associazione Italiana di Acustica, 2007 Jun; :215-222
Link
NIOSHTIC No.
20032553
Abstract
The goal of this study was to determine if vibration affects nitric oxide (NO)-mediated vasodilation in the ventral tail arteries of rats after exposure to a single bout of vibration. Male Sprague Dawley rats were restrained and their tails were exposed to a single 4 h bout of vibration at 125 Hz, 49 m/s2 r. m. s, or control conditions. Vascular levels of the synthetic enzymes, nitric oxide synthase (NOS)-1 and -3 were measured along with vascular NO concentrations. The sensitivity of the ventral artery to NO-induced vasodilation was also assessed in vitro. Exposure to a single bout of vibration reduced NOS-1 and NO concentrations in the ventral tail artery of vibrated animals, and resulted in a reduction in NO-mediated vasodilation that did not appear to be dependent upon endothelial cell activity. The reduced sensitivity of exposed arteries to NO-mediated vasodilation may make these blood vessels more susceptible to damage during subsequent exposures to vibration.
Keywords
Vibration-exposure; Vibration; Analytical-processes; Laboratory-animals; Animal-studies; Vibration-effects; Vibration-disease
Publication Date
20070601
Document Type
Conference/Symposia Proceedings
Editors
Bovenzi-M; Peretti-A; Nataletti-P; Moschioni-G
Fiscal Year
2007
NTIS Accession No.
NTIS Price
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
11th International Conference on Hand-Arm-Vibration, June 3-7, 2007, Bologna, Italy
State
WV
TOP