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In vitro system for applying cyclic loads to connective tissues under displacement or force control.

Authors
Asundi-KR; Kursa-K; Lotz-J; Rempel-DM
Source
Ann Biomed Eng 2007 Jul; 35(7):1188-1195
NIOSHTIC No.
20032487
Abstract
Overuse is thought to be the primary cause of chronic tendon injuries, in which forceful or repetitive loading results in an accumulation of micro-tears leading to a maladaptive repair response. In vitro organ culture models provide a useful method for examining how specific loading patterns affect the cellular response to load which may explain the early mechanisms of tissue injury associated with tendinopathies and ligament injuries. We designed a novel tissue loading system which employs closed-loop force feedback, capable of loading six tissue samples independently under force or displacement control. The system was capable of applying loads up to 40 N at rates of 100 N s(-1) and frequencies of 2 Hz, well above loads and rates measured in rabbit tendons in vivo. Loading parameters such as amplitude, rate, and frequency can be controlled while biomechanical factors such as creep, force relaxation, tangent modulus and Young's modulus can be assessed. The system can be used to examine the relationship between each loading parameter and biomechanical factors of connective tissues maintained in culture which may provide useful information regarding the etiology of overuse injuries.
Keywords
Biological-effects; Biological-function; Biomechanical-engineering; Biomechanical-modeling; Biomechanics; Cell-biology; Cellular-reactions; Ergonomics; Exposure-assessment; Exposure-levels; Exposure-methods; In-vitro-studies; In-vitro-study; Laboratory-animals; Laboratory-testing; Mechanics; Musculoskeletal-system; Musculoskeletal-system-disorders; Physiological-effects; Physiological-measurements; Physiological-response; Quantitative-analysis; Repetitive-work; Risk-analysis; Risk-factors; Statistical-analysis; Tension; Tissue-disorders; Author Keywords: Overuse injuries; Tendinopathies; Organ culture; Bioreactor; Mechanical stimulation
Contact
David M. Rempel, Ergonomics Program, Department of Bioengineering, University of California at Berkeley, 1301 South 46th Street, Building 163, Richmond, CA 94804
CODEN
ABMECF
Publication Date
20070701
Document Type
Journal Article
Email Address
david.rempel@ucsf.edu
Funding Type
Grant
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008429; Grant-Number-R01-OH-007359
Issue of Publication
7
ISSN
0090-6964
Source Name
Annals of Biomedical Engineering
State
CA
Performing Organization
University of California, Berkeley
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