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Antioxidant activity of Vaccinium stamineum: exhibition of anticancer capability in human lung and leukemia cells.

Authors
Wang-SY; Feng-RT; Bowman-L; Lu-YJ; Ballington-JR; Ding-M
Source
Planta Med 2007 May; 73(5):451-460
NIOSHTIC No.
20032382
Abstract
Fruit of deerberry [Vaccinium stamineum L.] were evaluated for their antioxidant capacity and anticancer properties in JB6 P+ mouse epidermal cells, human lung and leukemia cells. Deerberries contain potent free radical scavenging activities. Pretreatment of JB6 P+ mouse epidermal cells with deerberry fruit extracts produced an inhibition on the activation of activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappa B) induced by either 12-0-tetradecanoylphorbol 13-acetate (TPA) or ultraviolet-B (UVB). Deerberry fruit extracts also blocked TPA- or UVB-induced phosphorylation of ERKs and MEK 1/2, two upstream regulators of AP-1 and inhibited proliferation of human leukemia HL60 cancer cells and human lung epithelial cancer A549 cells and induced apoptosis of HL-60 cells. These results suggest that the inhibition of TPA- or UVB-induced AP-1 and NF-kappa B activity, inhibition of HL-60 cells and cancer A549 cells proliferation and induction of apoptotic in human leukemia HL-60 cancer cel Is may be mediated through the ERKs and MEK 1/2 signal pathway.
Keywords
Analytical-processes; Analytical-methods; Sensitivity-testing; Animal-studies; Lung-cancer; Lung-cells; Lung-disease; Lung-tissue; Cancer; Humans; Leukocytes; Antigens; Antibody-response
Contact
SY Wang, USDA ARS, Beltsville Agriculture Research Center, Agriculture Research Service, Fruit Laboratory, Beltsville, MD 20705
CODEN
PLMEAA
Publication Date
20070521
Document Type
Journal Article
Email Address
wangs@ba.ars.usda.gov
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0032-0943
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Planta Medica
State
WV; MD; SC
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