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The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone in the Third National Health and Nutrition Examination Survey.

Authors
Krieg-EF Jr.
Source
Environ Res 2007 Jul; 104(3):374-382
NIOSHTIC No.
20032324
Abstract
The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone were assessed in a nationally representative sample of women, 35-60 years old, from the third National Health and Nutrition Examination Survey. The blood lead levels of the women ranged from 0.7 to 31:1 mg/dl. The estimated geometric mean was 2:2 mg/dl, and the estimated arithmetic mean was 2:8 mg/dl. As the blood lead level increased across women, the concentration of serum follicle stimulating hormone increased in post-menopausal women, women who had both ovaries removed, and pre-menopausal women. The concentration of follicle stimulating hormone decreased in pre-menopausal women who were taking birth control pills. The concentration of luteinizing hormone increased as blood lead level increased in post-menopausal women and women who had both ovaries removed. The lowest concentrations of blood lead at which a relationship was detected were 1:7 mg/dl for follicle stimulating hormone and 2:8 mg/dl for luteinizing hormone. The increase in follicle stimulating hormone and luteinizing hormone in women with no ovaries indicates that lead may act at a non-ovarian site in the female reproductive system, along with a possible effect on the ovaries.
Keywords
Analytical-processes; Hormones; Hormone-activity; Women; Age-factors; Lead-absorption; Blood-analysis; Blood-serum; Reproduction; Reproductive-effects; Reproductive-system
Contact
EF Krieg Jr, National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, MS C-22, Cincinnati, OH 45226
CODEN
ENVRAL
Publication Date
20070701
Document Type
Journal Article
Email Address
erk3@cdc.gov
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0013-9351
NIOSH Division
DART
Source Name
Environmental Research
State
OH; CA
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