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Relationship between cumulative effects of smoking and memory CD4+ T lymphocyte subpopulations.

Authors
Nakata-A; Takahashi-M; Irie-M; Fujioka-Y; Haratani-T; Araki-S
Source
Addict Behav 2007 Jul; 32(7):1526-1531
NIOSHTIC No.
20032317
Abstract
Previous studies have found that smoking is a strong factor that increases peripheral blood CD4+ T lymphocytes. However, most studies did not assess the cumulative long-life exposure of smoking on differential lymphocyte populations. In this study, to clarify the association of smoking habits and circulating lymphocytes, we conducted a cross-sectional study of 60 male current smokers. Smoking status was estimated by number of cigarettes smoked per day, smoking years, and Brinkman Index (BI) as calculated by multiplying the number of cigarettes smoked per day by the smoking years. Counts of CD4+CD45RO+CD69+ T and CD4+CD45RO+ T lymphocytes were strongly and positively correlated with BI and remained highly significant after controlling for alcohol drinking, leisure-time physical activity, and caffeine intake (r(p)>.465, p<.001). These lymphocytes were also significantly correlated with the number of cigarettes smoked per day and smoking years, but the association was weaker than the BI. The findings suggest that the CD4+CD45RO+CD69+ T and CD4+CD45RO+ T lymphocytes are sensitive to cumulative effect of smoking, and may serve as a potential immuno-biomarker for active smoking.
Keywords
Exposure-levels; Time-weighted-average-exposure; Alcoholic-beverages; Physical-exercise; Blood-analysis; Immune-system; Immunological-tests; Biomarkers; Smoking; Men
Contact
A Nakata, National Institute for Occupational Safety and Health, MS-C24, 4676 Columbia Parkway, Cincinnati, OH 45226
CODEN
ADBEDS
Publication Date
20070701
Document Type
Journal Article
Email Address
nakataa-tky@umin.ac.jp
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Issue of Publication
7
ISSN
0306-4603
NIOSH Division
DART
Priority Area
All Sectors
Source Name
Addictive Behaviors
State
OH
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