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Serum levels of the extracellular domain of the epidermal growth factor receptor in individuals exposed to arsenic in drinking water in Bangladesh.

Authors
Li-Y; Chen-Y; Slavkovic-V; Ahsan-H; Parvez-F; Graziano-JH; Brandt-Rauf-PW
Source
Biomarkers 2007 May-Jun; 12(3):256-265
NIOSHTIC No.
20032313
Abstract
Epidermal growth factor receptor-dependent mechanisms have been implicated in growth signal transduction pathways that contribute to cancer development, including dermal carcinogenesis. Detection of the extracellular domain of the epidermal growth factor receptor (EGFR ECD) in serum has been suggested as a potential biomarker for monitoring this effect in vivo. Arsenic is a known human carcinogen, producing skin and other malignancies in populations exposed through their drinking water. One such exposed population, which we have been studying for a number of years, is in Bangladesh. The purpose of this study was to examine the EGFR ECD as a potential biomarker of arsenic exposure and/or effect in this population. Levels of the EGFR ECD were determined by enzyme-linked immunosorbent assay in the serum samples from 574 individuals with a range of arsenic exposures from drinking water in the Araihazar area of Bangladesh. In multiple regression analysis, serum EGFR ECD was found to be positively associated with three different measures of arsenic exposure (well water arsenic, urinary arsenic and a cumulative arsenic index) at statistically significant levels (p
Keywords
Risk-analysis; Epidemiology; Mathematical-models; Exposure-limits; Cancer-rates; Mutagens; Mutagenesis; Cancer; Biomarkers; Immune-reaction; Tumors; Risk-factors; Carcinogens; Carcinogenesis; Carcinogenicity; Dermatitis; Dermatosis; Skin-exposure; Skin-disorders; Skin-lesions; Skin-cancer; Water-analysis; Exposure-assessment; Exposure-levels; Exposure-methods
Contact
PW Brandt-Rauf, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 60 Haven Avenue, B-1, New York, NY 10032
CODEN
BIOMFA
CAS No.
7440-38-2
Publication Date
20070501
Document Type
Journal Article
Email Address
pwb1@columbia.edu
Funding Amount
163500
Funding Type
Grant
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-004192; Grant-Number-R01-OH-007590
Issue of Publication
3
ISSN
1354-750X
Source Name
Biomarkers
State
NY
Performing Organization
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
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