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A proposed testing framework for developmental immunotoxicology (DIT).

Authors
Holsapple-MP; Burns-Naas-LA; Hastings-KL; Ladics-GS; Lavin-AL; Makris-SL; Yang-Y; Luster-MI
Source
Toxicol Sci 2005 Jan; 83(1):18-24
NIOSHTIC No.
20032291
Abstract
A group of thirty immunotoxicology experts from the U.S. and E.U. representing government, industry, and academia met in May 2003, in Washington, D.C., to reach consensus regarding the most appropriate methods to assess developmental immunotoxicology (DIT) for hazard identification, including under what conditions such testing might be required. The following points represent the major conclusions from this roundtable discussion: (1) the rat is the preferred model; (2) any DIT protocol should be based on immune assays already validated; (3) DIT methods should be incorporated into standard developmental and reproductive toxicity protocols to the extent possible rather than a "stand-alone" protocol; (4) the approach to address DIT potential should be similar for chemicals and drugs, but the experimental design should be flexible and should reflect the specific questions to be answered; (5) it is possible to utilize a study design that assesses all critical windows in one protocol, with the results leading to further study of specific effects, as warranted; (6) animals should be exposed throughout the treatment protocol; (7) the triggers for DIT may include structure-activity-relationships, results from other toxicity studies, the intended use of a drug/chemical and/or its anticipated exposure of neonates and/or juveniles.
Keywords
Animal-studies; Reproductive-hazards; Toxic-effects; Toxins; Chemical-reactions; Chemical-hypersensitivity; Chemical-properties; Immunochemistry; Immunologic-disorders; Questionnaires; Age-factors; Quantitative-analysis
CODEN
TOSCF2
Publication Date
20050101
Document Type
Journal Article
Email Address
mholsapple@ilsi.org
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
1096-6080
NIOSH Division
HELD
Source Name
Toxicological Sciences
State
WV; DC; CA; MD; DE
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