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Temporal association of children's pesticide exposure and agricultural spraying: report of a longitudinal biological monitoring study.

Authors
Koch-D; Lu-C; Fisker-AJ; Jolley-L; Fenske-RA
Source
Environ Health Perspect 2002 Aug; 110(8):829-833
NIOSHTIC No.
20032257
Abstract
We measured organophosphorus (OP) pesticide exposures of young children living in an agricultural community over an entire year and evaluated the impact of agricultural spraying on exposure. We also examined the roles of age, sex, parental occupation, and residential proximity to fields. We recruited 44 children (2-5 years old) through a Women, Infants, and Children clinic. We collected urine samples on a biweekly basis over a 21-month period. Each child provided at least 16 urine samples, and most provided 26. We analyzed samples for the dialkylphosphate (DAP) metabolites common to the OP pesticides. DAP concentrations were elevated in months when OP pesticides were sprayed in the region's orchards. The geometric means of dimethyl and diethyl DAPs during spray months were higher than those during nonspray months (p = 0.009 for dimethyl; p = 0.018 for diethyl). Dimethyl DAP geometric means were 0.1 and 0.07 micro mol/L for spray months and nonspray months, respectively (57% difference); diethyl DAP geometric means were 0.49 and 0.35, respectively (40% difference). We also observed differences for sex of the child, with male levels higher than female levels (p = 0.005 for dimethyl; p = 0.046 for diethyl). We observed no differences due to age, parental occupation, or residential proximity to fields. This study reports for the first time the temporal pattern of pesticide exposures over the course of a full year and indicates that pesticide spraying in an agricultural region can increase children's exposure in the absence of parental work contact with pesticides or residential proximity to pesticide-treated farmland
Keywords
Exposure-levels; Exposure-limits; Pesticides; Pesticides-and-agricultural-chemicals; Biological-monitoring; Organo-phosphorus-compounds; Organo-phosphorus-pesticides; Occupational-exposure; Occupational-hazards; Occupational-health; Children; Urinalysis; Farmers
Contact
C. Lu, Box 357234, University of Washington, Seattle, WA 98195- 7234 USA
CODEN
EVHPAZ
Publication Date
20020801
Document Type
Journal Article
Email Address
calu@u.washington.edu
Funding Amount
868583
Funding Type
Cooperative Agreement
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U07-CCU-012926
Issue of Publication
8
ISSN
0091-6765
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
Environmental Health Perspectives
State
WA
Performing Organization
University of Washington, Seattle, Washington
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