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The effect of the 14-day agricultural restricted entry interval on azinphosmethyl exposures in a group of apple thinners in Washington State.

Authors
Fenske-RA; Curl-CL; Kissel-JC
Source
Regul Toxicol Pharmacol 2003 Aug; 38(1):91-97
NIOSHTIC No.
20032251
Abstract
We examined the effect of the 14-day agricultural restricted entry period on absorbed pesticide doses in a group of twenty experienced apple thinners. Thinners entered orchards 1-49 days following azinphosmethyl applications. Urine samples (n=296) collected throughout the thinning season were analyzed for the three dialkylphosphate metabolites of azinphosmethyl to estimate absorbed daily doses. Separate dose distributions were created for samples collected when the interval was <14 days, or 14 days or more; geometric mean doses for these two categories differed by a factor of two (42 and 19 g/kg/day, respectively; p<0.0001). Dose estimates were compared to US Environmental Protection Agency and California EPA regulatory guidance values for occupational azinphosmethyl risk. None of the doses exceeded the U.S. EPA NOAEL (560 g/kg/day), but nearly all had a margin of exposure of less than 100. Addition of a 10-fold uncertainty factor to California EPAs NOAEL produced a guidance value of 75 g/kg/day. Only 2.4% of the doses exceeded this value for re-entry intervals 14 days or more, while 27% exceeded the value for re-entry intervals <14 days. We conclude that the 14-day restricted entry interval provides an appropriate level of worker health protection under the field conditions studied.
Keywords
Agriculture; Agricultural-chemicals; Exposure-levels; Pesticides; Absorption-rates; Occupational-exposure; Occupational-hazards; Occupational-health; Health-hazards; Urinalysis
Contact
Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195-7234
CODEN
RTOPDW
CAS No.
86-50-0
Publication Date
20030801
Document Type
Journal Article
Email Address
rfenske@u.washington.edu
Funding Type
Cooperative Agreement
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U50-OH-007544
Issue of Publication
1
ISSN
0273-2300
Source Name
Regulatory Toxicology and Pharmacology
State
WA
Performing Organization
University of Washington
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