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Size exclusion chromatographic cleanup for GC/MS determination of organophosphorus pesticide residues in household and vehicle dust.

Authors
Moate-TF; Furia-M; Curl-C; Muniz-JF; Yu-J; Fenske-RA
Source
J AOAC Int 2002 Jan-Feb; 85(1):36-43
NIOSHTIC No.
20032232
Abstract
Size exclusion chromatography (SEC) was used as a cleanup method for the analysis of organophosphorus pesticides in household and vehicle dusts. The pesticides investigated were diazinon, methyl parathion, chlorpyrifos, malathion, phosmet, and azinphosmethyl. These compounds are of interest due to their use in agricultural tree fruit production and/or urban pest control. Pesticides were determined via gas chromatography/mass spectrometry with selected-ion monitoring and cool on-column injection. The lower limit of method validation was 0.20 microg/g. Method limits of detection in dust ranged from 0.012-0.055 microg/g. Dust samples were collected with vacuums from the homes and vehicles of people living and working in a rural agricultural region in the central part of Washington State. The analytes were extracted from the dust by sonication in acetone. The extracts were solvent-exchanged to cyclohexane, frozen, thawed, and centrifuged prior to SEC injection. Following SEC, the eluent was split into 2 fractions, concentrated, and injected on-column into the gas chromatograph. This method represents the first complete publication describing the SEC cleanup of organophosphorus pesticides in dusts. Recoveries of pesticides in dusts ranged from 63.5-110.8 +/- 4.9-19.6% over a fortification range of 0.20-10.00 microg/g. This optimized, automated, and reproducible SEC method does not require further treatment or cleanup for trace determination of these organophosphorus pesticides
Keywords
Organo-phosphorus-compounds; Organo-phosphorus-pesticides; Dust-collection; Dust-analysis; Dust-exposure; Agricultural-industry; Agricultural-products; Agricultural-chemicals; Agricultural-workers; Pesticides; Samplers; Sampling; Treatment; Exposure-assessment; Exposure-limits
Contact
University of Washington, Environmental Health Laboratory, Seattle 98195-7234
CODEN
JAINEE
CAS No.
333-41-5; 298-00-0; 2921-88-2; 121-75-5; 732-11-6; 86-50-0; 110-83-8
Publication Date
20020101
Document Type
Journal Article
Email Address
tmoate@snblusa.com
Funding Amount
868583
Funding Type
Cooperative Agreement
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U07-CCU-012926
Issue of Publication
1
ISSN
1060-3271
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
Journal of AOAC International
State
WA
Performing Organization
University of Washington
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