The clinical laboratory in the diagnosis of overexposure to agrochemicals.
Lab Med 1998 Nov; 29(11):689-695
Pesticides are the most toxic agrochemicals, and the World Health Organization estimates that 3 million acute pesticide poisonings occur yearly worldwide, with about 220,000 deaths. Others estimate the annual global toll of poisonings at 25 million. The cholinesterase inhibitors (organophosphates and N-methyl carbamates) are the chemical pesticides most commonly implicated in poisonings, but other pesticides, including herbicides, fungicides, and fumigants, may cause illness. Despite these numbers, even rural clinicians rarely see agrochemical poisonings. While many assays are available only at specialty laboratories, the informed laboratory specialist can help enormously in solving puzzling cases, obtaining important legal evidence, and ruling out exposure when not present.
Agricultural-chemicals; Agriculture; Toxic-effects; Pesticides; Pesticides-and-agricultural-chemicals; Poisons; Cholinesterase-inhibitors; Chemical-properties; Chemical-synthesis; Herbicides; Fungicides; Fumigants; Exposure-limits; Exposure-levels
Neurotoxic Disorders; Neurotoxic-effects
University of Washington, Seattle, Washington