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Restraint-induced modulation of allergic and irritant contact dermatitis in male and female B6.129 mice.

Authors
Flint-MS; Miller-DB; Tinkle-SS
Source
Brain Behav Immun 2000 Dec; 14(4):256-269
NIOSHTIC No.
20032180
Abstract
Recent studies in rats have indicated that acute restraint enhances cutaneous hypersensitivity. We hypothesized that acute restraint would also modulate the development of allergic and irritant dermatitis in mice and that these restraint-induced changes would be reflected in the cutaneous cytokine profile and be gender-specific. For these studies, male and female B6.129 mice were sensitized and challenged with the contact sensitizer dinitrofluorobenzene or challenged with the irritant croton oil. Two-hour restraint was applied prior to chemical challenge. Restraint combined with chemical increased ear swelling in both genders in ACD, a change that was blocked by administration of RU-486 prior to restraint. Neither restraint nor RU-486 administration modulated development of ICD; however, IL-1 beta was decreased by restraint in females only. TNF-alpha and IFN-gamma production were modified in ACD; TNF-alpha in both genders and IFN-gamma in female mice only. Our data demonstrate that acute restraint increases serum corticosterone in B6.129 male and female mice to comparable levels. Restraint modulated the murine ear swelling in ACD, but not ICD, in both genders, and the change in the ear swelling response and cytokine production were, at least in part, corticosterone-dependent.
Keywords
Contact-allergies; Contact-dermatitis; Allergens; Allergic-dermatitis; Allergic-reactions; Allergies; Sensitization; Immune-reaction; Immune-system; Dermatitis; Skin-irritants; Skin-sensitivity; Skin-disorders; Laboratory-animals; Animal-studies
Contact
NIOSH, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, 26505
CODEN
BBIMEW
Publication Date
20001201
Document Type
Journal Article
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
0889-1591
NIOSH Division
HELD
Source Name
Brain, Behavior, and Immunity
State
WV
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