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Risk of laryngeal cancer by occupational chemical exposure in Turkey.

Authors
Elci-OC; Akpinar-Elci-M; Blair-A; Dosemeci-M
Source
J Occup Environ Med 2003 Oct; 45(10):1100-1106
NIOSHTIC No.
20032142
Abstract
Laryngeal cancer is the second most common cancer among men in Turkey. In this hospital based case-control study, we evaluated laryngeal cancer risks from occupational chemical exposures. We analyzed 940 laryngeal cancer cases and 1519 controls. Occupational history, tobacco, and alcohol use and demographic information were obtained by a questionnaire. The job and industries were classified by special seven-digit codes. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) based on a developed exposure matrix for chemicals, including diesel exhaust, gasoline exhaust, polycyclic aromatic hydrocarbons (PAHs), formaldehyde, and solvents. An excess of laryngeal cancer occurred with diesel exhaust (OR = 1.5, 95% CI = 1.3-1.9), gasoline exhaust (OR = 1.6, 95% CI = 1.3-2.0), and PAHs (OR = 1.3, 95% CI = 1.1-1.6). There was a dose-response relationship for these substances with supraglottic cancers (P < 0.000). The PAH association only occurred among those who also had exposure to diesel exhaust.
Keywords
Larynx-cancer; Occupational-exposure; Risk-analysis; Risk-factors; Respiratory-system-disorders; Cancer; Men; Demographic-characteristics; Smoking; Alcoholic-beverages; Questionnaires; Diesel-exhausts; Polycyclic-aromatic-hydrocarbons; Formaldehydes; Solvents; Natural-gas; Dose-response; Throat; Throat-disorders; Fuels; Exhaust-gases
Contact
National Institute for Occupational Safety and Health, Division of Respiratory Diseases Studies, Field Studies Branch, MS2800, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
JOEMFM
CAS No.
50-00-0
Publication Date
20031001
Document Type
Journal Article
Email Address
oae3@cdc.gov
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Issue of Publication
10
ISSN
1076-2752
NIOSH Division
DRDS
Source Name
Journal of Occupational and Environmental Medicine
State
MD; WV
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