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Children's exposure to chlorpyrifos and parathion in an agricultural community in central Washington State.

Authors
Fenske-RA; Lu-C; Barr-D; Needham-L
Source
Environ Health Perspect 2002 May; 110(5):549-553
NIOSHTIC No.
20032141
Abstract
We measured two diethyl organophosphorus (OP) pesticides chlorpyrifos and parathionlin residences, and their metabolic by-products, in the urine of children 6 years old or younger in a central Washington State agricultural community. Exposures to two dimethyl OP pesticides (azinphos-methyl and phosmet) in this same population have been reported previously. We categorized children by parental occupation and by household proximity to pesticide-treated farm- land. Median chlorpyrifos house dust concentrations were highest for the 49 applicator homes followed by the 12 farm-worker homes and the 14 nonagricultural reference homes), and were statistically different ; we observed a similar pattern for parathion in house dust. Chlorpyrifos was measurable in the house dust of all homes, whereas we found parathion in only 41% ofthe homes. Twenty-four percent ofthe urine samples from study children had measurable 3,5,6-trichloro-2-pyridinol (TCPy) concentrations limits of quantitation, and 7% had measurable 4-nitrophenol concentrations. Child urinary metabolite concentrations did not differ across parental occupational classifications. Homes in close proximity to pesticide-treated farmland had higher chlorpyrifos and parathion house dust concentrations than did homes farther away, but this effect was not reflected in the urinary metabolite data. Use of OP pesticides in the garden was associated with an increase in TCPy concentrations in children's urine. Parathion concentrations in house dust decreased 10-fold from 1992 to 1995, consistent with the discontinued use of this product in the region in the early 1990s. Key words agriculture, children, chiorpyrifos, exposure, house dust, organophosphorus, parathion, pesticides, urinary metabolites.
Keywords
Agriculture; Agricultural-workers; Agricultural-chemicals; Children; Exposure-levels; Exposure-limits; Pesticides; Workers; Farmers; Families; Dust-sampling; Dust-measurement; Dust-samplers; Organo-phosphorus-compounds; Urinalysis
Contact
R. Fenske, Department of Environmental Health, Box 357234, University of Washington, Seattle, WA 98195-7234 USA
CODEN
EVHPAZ
Publication Date
20020501
Document Type
Journal Article
Email Address
rfenske@u.washington.edu
Funding Amount
868583
Funding Type
Cooperative Agreement
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U07-CCU-012926
Issue of Publication
5
ISSN
0091-6765
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
Environmental Health Perspectives
State
WA; GA
Performing Organization
University of Washington, Seattle, Washington
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