Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Aging, estradiol and time of day differentially affect serotonin transporter binding in the central nervous system of female rats.

Authors
Krajnaka-K; Rosewell-KL; Duncan-MJ; Wise-PM
Source
Brain Res 2003 Nov; 990(1-2):87-94
NIOSHTIC No.
20032138
Abstract
Estrogen-related changes in serotonergic neuronal transmission, including changes in the number of serotonin transporter (SERT) binding sites, have been cited as a possible cause for changes in mood, memory and sleep that occur during the menopausal transition. However, both aging and estradiol regulate SERT binding sites in the brain. The goal of this experiment was to determine how aging and estrogen interact to regulate SERT levels in the forebrain of young and reproductively senescent female Sprague-Dawley rats using [3H]paroxetine. The density of specific [3H]paroxetine binding in various brain regions was compared in young (2-4 months) and reproductively senescent (10-12 months) female rats at three times of day. In most brain regions examined, estrogen and aging independently increased the number of [3H]paroxetine binding sites. The only region that displayed a reduction in [3H]paroxetine binding with age was the suprachiasmatic nucleus (SCN). Time of day influenced [3H]paroxetine binding in the SCN and the paraventricular thalamus (PVT), two regions known to be involved in the regulation of circadian rhythms. Aging and/or estrogen also altered the pattern of binding in these regions. Thus, based on the results of this study, we conclude that aging and estrogen both act to regulate SERT binding sites in the forebrain of female rats, and that this regulation is region specific.
Keywords
Laboratory-animals; Animal-studies; Animals; Brain-function; Estrogenic-hormones; Neurotransmitters; Age-factors; Central-nervous-system; Steroids; Reproductive-effects; Circadian-rhythms
Contact
National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Engineering and Control Technology Branch, MS2027, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
BRREAP
CAS No.
61869-08-7
Publication Date
20031114
Document Type
Journal Article
Email Address
mqk1@cdc.gov
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Issue of Publication
1-2
ISSN
0006-8993
NIOSH Division
HELD
Source Name
Brain Research
State
CA; KY; WV
TOP